Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor.

Threonine-tRNA Ligase Escherichia coli Adenine Nucleotides

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
05 07 2023
Historique:
medline: 6 7 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: epublish

Résumé

An analogue of a toxic moiety (TM84) of natural product agrocin 84 containing threonine amide instead of 2,3-dihydroxy-4-methylpentanamide was prepared and evaluated as a putative

Identifiants

DOI: 10.1039/d3ob00670k PMID: 37335076
pubmed: 37335076
doi: 10.1039/d3ob00670k
doi:

Substances chimiques

Threonine-tRNA Ligase EC 6.1.1.3
agrocin 84 59111-78-3
borrelidin 7184-60-3
Adenine Nucleotides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5433-5439

Auteurs

Jhon Alexander Rodriguez Buitrago (JAR)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.

Gundars Leitis (G)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.

Iveta Kaņepe-Lapsa (I)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.

Anastasija Rudnickiha (A)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.

Emilio Parisini (E)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Department of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy. emilio.parisini@osi.lv.

Aigars Jirgensons (A)

Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
ORCID: 0000-0002-8937-8792

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-oxygen ligases › Amino acyl-tRNA synthetases › Threonine-tRNA ligase › Synthesis and evaluation of an agrocin 84...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Synthesis and evaluation of an agrocin 84...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Synthesis and evaluation of an agrocin 84...