DNA Transport through the Dynamic Type IV Secretion System.
DNA conjugation
T4SS
competence
host-pathogen interactions
type IV secretion system
Journal
Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127
Informations de publication
Date de publication:
18 07 2023
18 07 2023
Historique:
pmc-release:
20
12
2023
medline:
21
7
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial pathogenesis and the propagation of antibiotic resistance determinants throughout microbial populations. In addition to paradigmatic DNA conjugation machineries, diverse T4SSs enable the delivery of multifarious effector proteins to target prokaryotic and eukaryotic cells, mediate DNA export and uptake from the extracellular milieu, and in rare examples, facilitate transkingdom DNA translocation. Recent advances have identified new mechanisms underlying unilateral nucleic acid transport through the T4SS apparatus, highlighting both functional plasticity and evolutionary adaptations that enable novel capabilities. In this review, we describe the molecular mechanisms underscoring DNA translocation through diverse T4SS machineries, emphasizing the architectural features that implement DNA exchange across the bacterial membrane and license transverse DNA release across kingdom boundaries. We further detail how recent studies have addressed outstanding questions surrounding the mechanisms by which nanomachine architectures and substrate recruitment strategies contribute to T4SS functional diversity.
Identifiants
pubmed: 37338415
doi: 10.1128/iai.00436-22
pmc: PMC10353360
doi:
Substances chimiques
Type IV Secretion Systems
0
Bacterial Proteins
0
DNA
9007-49-2
DNA, Bacterial
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0043622Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130456
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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