Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers.
c-mpl ligand
cancer biology
cytokine receptor
helix dimerization
human
molecular biophysics
mouse
structural biology
thrombopoietin receptor
transmembrane domain
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 Jun 2023
20 Jun 2023
Historique:
received:
30
06
2022
accepted:
19
06
2023
medline:
3
7
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
epublish
Résumé
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. Here we addressed the structural basis of activation for receptor mutations S505N and W515K that induce myeloproliferative neoplasms. We show using
Identifiants
pubmed: 37338955
doi: 10.7554/eLife.81521
pii: 81521
pmc: PMC10313314
doi:
pii:
Substances chimiques
Receptors, Thrombopoietin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM046732
Pays : United States
Informations de copyright
© 2023, Defour, Leroy, Dass et al.
Déclaration de conflit d'intérêts
JD, EL, SD, TB, GL, IB, NP, CM, LG, CP, JS, SS No competing interests declared, SC is co-founder of MyeloPro Diagnostics and Research GmbH, Vienna, Austria
Références
Mol Endocrinol. 2007 Jul;21(7):1642-55
pubmed: 17456794
J Gen Physiol. 2005 Jul;126(1):41-53
pubmed: 15955874
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33384332
J Biol Chem. 1994 Oct 21;269(42):26208-14
pubmed: 7929335
Blood. 2010 Feb 4;115(5):1037-48
pubmed: 19996410
Oncogene. 2007 Oct 15;26(47):6715-23
pubmed: 17934480
Mol Cell Biol. 1997 May;17(5):2497-501
pubmed: 9111318
Blood. 1998 Jul 1;92(1):4-10
pubmed: 9639492
Mol Cell. 2001 Dec;8(6):1327-38
pubmed: 11779507
EMBO J. 2011 Sep 02;30(21):4398-413
pubmed: 21892137
PLoS Med. 2006 Jul;3(7):e270
pubmed: 16834459
Structure. 2020 Sep 1;28(9):1004-1013.e4
pubmed: 32470317
Mol Cell. 2001 Feb;7(2):377-85
pubmed: 11239466
Annu Rev Cell Dev Biol. 1996;12:91-128
pubmed: 8970723
Nat Struct Biol. 2000 Feb;7(2):154-60
pubmed: 10655619
Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2540-5
pubmed: 23359689
Cell. 2015 Mar 12;160(6):1196-208
pubmed: 25728669
FASEB J. 2011 Jul;25(7):2234-44
pubmed: 21402716
Mol Endocrinol. 2006 Aug;20(8):1912-23
pubmed: 16556730
Nature. 1994 Jun 16;369(6481):568-71
pubmed: 8202159
Nat Methods. 2006 Dec;3(12):977-9
pubmed: 17099704
J Biol Chem. 2005 Jul 22;280(29):27251-61
pubmed: 15899890
Blood. 2004 Jun 1;103(11):4198-200
pubmed: 14764528
PLoS Comput Biol. 2011 Oct;7(10):e1002204
pubmed: 22028633
J Mol Biol. 1992 May 20;225(2):487-94
pubmed: 1593632
Science. 2014 May 16;344(6185):1249783
pubmed: 24833397
Elife. 2018 Jul 25;7:
pubmed: 30044226
Biochemistry. 2008 Nov 11;47(45):11771-82
pubmed: 18855427
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Blood. 2006 Nov 15;108(10):3472-6
pubmed: 16868251
Nucleic Acids Res. 2022 Jan 7;50(D1):D439-D444
pubmed: 34791371
J Biol Chem. 2016 Feb 5;291(6):2974-87
pubmed: 26627830
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1646-51
pubmed: 23319611
J Mol Biol. 2016 Nov 20;428(23):4651-4668
pubmed: 27725180
J Biol Chem. 2019 Apr 12;294(15):5854-5866
pubmed: 30755484
Blood. 2006 Mar 1;107(5):1864-71
pubmed: 16249382
Annu Rev Biophys Biophys Chem. 1986;15:321-53
pubmed: 3521657
Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6
pubmed: 21841788
Clin Cancer Res. 2016 Feb 1;22(3):757-64
pubmed: 26475333
Anal Biochem. 2000 Apr 10;280(1):20-8
pubmed: 10805516
Biochemistry. 1989 Nov 14;28(23):8972-9
pubmed: 2690953
Leukemia. 2016 May;30(5):1214-6
pubmed: 26437785
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3579-84
pubmed: 24522108
Biochemistry. 1998 Oct 20;37(42):14713-8
pubmed: 9778346
Blood. 2020 Mar 19;135(12):948-953
pubmed: 31978223
Cell Stem Cell. 2007 Dec 13;1(6):685-97
pubmed: 18371409
J Allergy Clin Immunol. 2019 Jul;144(1):224-235
pubmed: 30707971
Nat Struct Biol. 2000 Feb;7(2):161-6
pubmed: 10655620
Cell Stem Cell. 2007 Dec 13;1(6):671-84
pubmed: 18371408
Mol Biol Cell. 2000 Oct;11(10):3589-99
pubmed: 11029057
Nat Struct Mol Biol. 2014 May;21(5):443-8
pubmed: 24704786
Blood. 2009 Oct 8;114(15):3325-8
pubmed: 19483125
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4379-84
pubmed: 11296286
J Clin Invest. 2002 Aug;110(3):389-94
pubmed: 12163458
Blood. 2008 Jul 1;112(1):141-9
pubmed: 18451306
Biochem Biophys Res Commun. 2006 Aug 4;346(3):649-57
pubmed: 16774741
Science. 2022 Apr 8;376(6589):163-169
pubmed: 35271300
Sci Rep. 2016 Sep 23;6:34129
pubmed: 27658480
Science. 2020 Feb 7;367(6478):643-652
pubmed: 32029621
Biochemistry. 1999 Jul 27;38(30):9778-82
pubmed: 10423258
Diagn Mol Pathol. 2011 Mar;20(1):34-9
pubmed: 21326037
Nat Struct Mol Biol. 2012 Aug;19(8):754-9
pubmed: 22820988
Mol Cell Biol. 2000 May;20(10):3387-95
pubmed: 10779328