Ion channel selectivity through ion-modulated changes of selectivity filter p
molecular dynamics
pKa values
selectivity
sodium channel
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
27 06 2023
27 06 2023
Historique:
pmc-release:
20
12
2023
medline:
22
6
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
In bacterial voltage-gated sodium channels, the passage of ions through the pore is controlled by a selectivity filter (SF) composed of four glutamate residues. The mechanism of selectivity has been the subject of intense research, with suggested mechanisms based on steric effects, and ion-triggered conformational change. Here, we propose an alternative mechanism based on ion-triggered shifts in p
Identifiants
pubmed: 37339196
doi: 10.1073/pnas.2220343120
pmc: PMC10293820
doi:
Substances chimiques
Ions
0
Voltage-Gated Sodium Channels
0
Glutamates
0
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2220343120Subventions
Organisme : Intramural NIH HHS
ID : ZIA HL001050
Pays : United States
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