Design, synthesis, in vitro anti-α-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents.
Humans
Diabetes Mellitus, Type 2
/ metabolism
Structure-Activity Relationship
Molecular Docking Simulation
alpha-Glucosidases
/ metabolism
Acetamides
/ pharmacology
Triazoles
/ pharmacology
Kinetics
Hypoglycemic Agents
/ chemistry
Glycoside Hydrolase Inhibitors
/ chemistry
Phthalimides
/ pharmacology
Molecular Structure
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 06 2023
20 06 2023
Historique:
received:
29
11
2022
accepted:
12
06
2023
medline:
22
6
2023
pubmed:
21
6
2023
entrez:
20
6
2023
Statut:
epublish
Résumé
An important target in the treatment of type 2 diabetes is α-glucosidase. Inhibition of this enzyme led to delay in glucose absorption and decrease in postprandial hyperglycemia. A new series of phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides 11a-n were designed based on the reported potent α-glucosidase inhibitors. These compounds were synthesized and screened for their in vitro inhibitory activity against the latter enzyme. The majority of the evaluated compounds displayed high inhibition effects (IC
Identifiants
pubmed: 37340010
doi: 10.1038/s41598-023-36890-y
pii: 10.1038/s41598-023-36890-y
pmc: PMC10282079
doi:
Substances chimiques
alpha-Glucosidases
EC 3.2.1.20
Acetamides
0
Triazoles
0
Hypoglycemic Agents
0
Glycoside Hydrolase Inhibitors
0
Phthalimides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10030Informations de copyright
© 2023. The Author(s).
Références
Eur J Med Chem. 2015 Nov 13;105:156-70
pubmed: 26491979
Bioorg Med Chem. 2010 Aug 15;18(16):5903-14
pubmed: 20667739
Nucleic Acids Res. 2009 Jan;37(Database issue):D387-92
pubmed: 18931379
Chem Biol Drug Des. 2016 Mar;87(3):361-73
pubmed: 26362113
J Cell Physiol. 2017 Dec;232(12):3631-3640
pubmed: 28145580
Bioorg Chem. 2020 Jan;95:103482
pubmed: 31838286
Expert Opin Pharmacother. 2019 Dec;20(18):2229-2235
pubmed: 31593486
Plants (Basel). 2022 Oct 14;11(20):
pubmed: 36297746
Food Sci Nutr. 2020 Nov 04;8(12):6320-6337
pubmed: 33312519
Bioorg Med Chem. 2008 Apr 15;16(8):4272-85
pubmed: 18343126
J Med Chem. 2020 Apr 23;63(8):4205-4214
pubmed: 32227946
Biochemistry (Mosc). 2011 Jun;76(6):622-35
pubmed: 21639842
Antiviral Res. 2007 Oct;76(1):30-7
pubmed: 17548120
Eur J Med Chem. 2019 Aug 15;176:343-377
pubmed: 31112894
J Comput Chem. 2011 Aug;32(11):2359-68
pubmed: 21541964