Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
23 06 2023
23 06 2023
Historique:
medline:
23
6
2023
pubmed:
21
6
2023
entrez:
21
6
2023
Statut:
ppublish
Résumé
Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, and structural studies of purified systems were essential for our understanding of the function of the individual complexes involved, they cannot resolve how the actions of individual complexes integrate. We used cryo-electron tomography to simultaneously image multiple presynaptic protein complexes and lipids at molecular resolution in their native composition, conformation, and environment. Our detailed morphological characterization suggests that sequential synaptic vesicle states precede neurotransmitter release, where Munc13-comprising bridges localize vesicles <10 nanometers and soluble
Identifiants
pubmed: 37343100
doi: 10.1126/sciadv.adf6222
pmc: PMC10284560
doi:
Substances chimiques
Neurotransmitter Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadf6222Références
Annu Rev Biophys. 2018 May 20;47:469-497
pubmed: 29792815
Ultramicroscopy. 2014 Aug;143:15-23
pubmed: 24332462
Elife. 2014 Feb 11;3:e01715
pubmed: 24520164
Neuroscience. 1991;40(2):587-98
pubmed: 2027472
J Neurocytol. 1993 Sep;22(9):735-42
pubmed: 7903689
Cell. 2004 Aug 6;118(3):389-401
pubmed: 15294163
J Neurosci. 2018 Feb 7;38(6):1493-1510
pubmed: 29311144
Neuron. 2014 Oct 22;84(2):416-31
pubmed: 25374362
Neuron. 2020 Dec 9;108(5):843-860.e8
pubmed: 32991831
J Neurosci. 2007 Aug 29;27(35):9380-91
pubmed: 17728451
Int J Mol Sci. 2019 Apr 30;20(9):
pubmed: 31052288
Nat Commun. 2018 Sep 26;9(1):3943
pubmed: 30258069
J Biol Chem. 1996 Jun 14;271(24):14548-53
pubmed: 8662851
Nat Methods. 2007 Mar;4(3):215-7
pubmed: 17277781
Nat Rev Mol Cell Biol. 2006 Sep;7(9):631-43
pubmed: 16912714
Biochem Soc Trans. 2005 Dec;33(Pt 6):1345-9
pubmed: 16246115
FEBS Open Bio. 2023 Jan;13(1):26-50
pubmed: 36305864
Nature. 2015 Sep 3;525(7567):62-7
pubmed: 26280336
J Neurosci. 2006 Aug 2;26(31):8040-7
pubmed: 16885217
J Struct Biol. 2007 Nov;160(2):146-56
pubmed: 17905597
Nat Protoc. 2006;1(5):2406-15
pubmed: 17406484
J Struct Biol. 2017 Feb;197(2):73-82
pubmed: 27444390
J Struct Biol. 2017 Feb;197(2):191-198
pubmed: 27313000
Annu Rev Biochem. 1999;68:863-911
pubmed: 10872468
Curr Opin Struct Biol. 2019 Feb;54:129-138
pubmed: 30925443
Science. 2014 May 30;344(6187):1023-8
pubmed: 24876496
J Biol Chem. 1995 Dec 1;270(48):28495-8
pubmed: 7499357
EMBO Rep. 2023 May 4;24(5):e55719
pubmed: 36876590
J Comp Neurol. 2011 Oct 15;519(15):3019-39
pubmed: 21618221
FEBS Lett. 2009 Dec 3;583(23):3770-83
pubmed: 19887069
Neuron. 2012 Jul 12;75(1):11-25
pubmed: 22794257
Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9110-9115
pubmed: 28739947
Neuron. 2013 Oct 30;80(3):675-90
pubmed: 24183019
Neuron. 2002 Jan 31;33(3):397-409
pubmed: 11832227
Neuron. 2018 Dec 19;100(6):1283-1291
pubmed: 30571941
Science. 2001 Nov 2;294(5544):1117-22
pubmed: 11691998
Curr Opin Struct Biol. 2019 Feb;54:152-160
pubmed: 30904821
J Neurochem. 1999 Apr;72(4):1699-706
pubmed: 10098880
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):
pubmed: 35135883
Nat Neurosci. 2020 Dec;23(12):1589-1596
pubmed: 33139942
Nature. 2020 Sep;585(7825):357-362
pubmed: 32939066
Elife. 2017 Feb 08;6:
pubmed: 28177287
Biophys J. 2016 Feb 23;110(4):850-9
pubmed: 26743046
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702
pubmed: 17301226
Nat Neurosci. 2002 Jan;5(1):19-26
pubmed: 11753414
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4548-57
pubmed: 27432975
J Struct Biol. 1997 Dec;120(3):276-308
pubmed: 9441933
Curr Opin Neurobiol. 2011 Apr;21(2):261-8
pubmed: 21247753
J Neurosci Methods. 1991 Apr;37(2):173-82
pubmed: 1715499
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4449-54
pubmed: 22392984
J Cell Biol. 1989 Jan;108(1):111-26
pubmed: 2536030
Science. 2013 Jan 25;339(6118):421-5
pubmed: 23258414
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42
pubmed: 12070347
J Neurochem. 2011 Feb;116(4):476-85
pubmed: 21143597
PLoS Biol. 2007 Aug;5(8):e198
pubmed: 17645391
Neuron. 2021 Dec 15;109(24):3980-4000.e7
pubmed: 34706220
Structure. 2005 Mar;13(3):423-34
pubmed: 15766544
Nat Neurosci. 2018 Jan;21(1):33-40
pubmed: 29230057
Nature. 1986 Jun 19-25;321(6072):772-3
pubmed: 3713864
Elife. 2019 Feb 28;8:
pubmed: 30816091
Neuron. 2003 Dec 4;40(5):945-57
pubmed: 14659093
Cell Rep. 2021 Mar 16;34(11):108842
pubmed: 33730593
Curr Opin Neurobiol. 2018 Aug;51:147-153
pubmed: 29902592
Neuron. 2007 Apr 19;54(2):275-90
pubmed: 17442248
Annu Rev Biochem. 2005;74:833-65
pubmed: 15952904
Neuron. 2015 Sep 23;87(6):1131-1142
pubmed: 26402599
J Neurosci. 2006 Jan 25;26(4):1239-46
pubmed: 16436611
J Neurosci. 2013 Oct 16;33(42):16698-714
pubmed: 24133272
Neuron. 2013 Jul 10;79(1):82-96
pubmed: 23770256
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
J Neurosci. 2019 Apr 24;39(17):3175-3187
pubmed: 30792272
Neuron. 2017 Apr 19;94(2):304-311.e4
pubmed: 28426965
J Neurochem. 2007 Jun;101(6):1471-82
pubmed: 17286592
Nature. 1999 Dec 2;402(6761 Suppl):C47-52
pubmed: 10591225
J Cell Biol. 2010 Jan 11;188(1):145-56
pubmed: 20065095
J Neurosci Methods. 2012 Nov 15;211(2):289-95
pubmed: 23017979
J Microsc. 2010 Jan;237(1):23-38
pubmed: 20055916
J Biochem. 2000 Sep;128(3):407-14
pubmed: 10965039
J Struct Biol. 2016 Dec;196(3):503-514
pubmed: 27742578
Cell Rep. 2017 Jan 3;18(1):161-173
pubmed: 28052246
Nature. 2016 Aug 11;536(7615):210-4
pubmed: 27462810
Elife. 2015 Aug 11;4:
pubmed: 26259873
Eur J Neurosci. 2009 Jul;30(1):49-56
pubmed: 19558619
Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):
pubmed: 33468631
Protein Sci. 2018 Aug;27(8):1364-1391
pubmed: 29893445
Mol Cell Neurosci. 2020 Jan;102:103452
pubmed: 31794878
Nature. 2012 Oct 11;490(7419):201-7
pubmed: 23060190
Sci Adv. 2021 Mar 5;7(10):
pubmed: 33674312
J Neurosci. 2007 Jun 27;27(26):6868-77
pubmed: 17596435
Brain Res. 1988 Feb 16;441(1-2):59-71
pubmed: 2834006
Neuron. 1988 May;1(3):201-9
pubmed: 3152289
Cell. 2002 Jan 11;108(1):121-33
pubmed: 11792326
Annu Rev Biochem. 2017 Jun 20;86:873-896
pubmed: 28426242
Nature. 1999 Jul 29;400(6743):457-61
pubmed: 10440375
Nat Neurosci. 2020 Nov;23(11):1329-1338
pubmed: 32989294
J Neurochem. 1987 Jul;49(1):50-7
pubmed: 2884279
Neuron. 2011 Jan 27;69(2):317-31
pubmed: 21262469
Nat Protoc. 2008;3(11):1718-28
pubmed: 18927557
J Neurosci. 2021 Sep 1;41(35):7329-7339
pubmed: 34290081
Nature. 2002 Jan 17;415(6869):321-6
pubmed: 11797009
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
Cell Rep. 2020 Mar 17;30(11):3632-3643.e8
pubmed: 32187536
J Struct Biol. 2010 Nov;172(2):169-79
pubmed: 20178848
J Cell Biol. 2013 May 27;201(5):725-40
pubmed: 23712261
Nature. 2017 Aug 24;548(7668):420-425
pubmed: 28813412
Biotechnol J. 2009 Jun;4(6):888-94
pubmed: 19492330
PLoS One. 2018 Jun 4;13(6):e0197886
pubmed: 29864134
Eur J Neurosci. 2000 Jan;12(1):385-90
pubmed: 10651895
J Struct Biol. 1996 Jan-Feb;116(1):71-6
pubmed: 8742726
J Biol Chem. 2010 Jun 4;285(23):17907-17
pubmed: 20375012
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
Cell. 2011 Jan 21;144(2):282-95
pubmed: 21241895
Nat Struct Mol Biol. 2010 Mar;17(3):280-8
pubmed: 20154707
J Neurosci. 2007 Jan 31;27(5):1200-10
pubmed: 17267576
Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15635-40
pubmed: 25331897
J Neurosci. 2016 Mar 16;36(11):3222-30
pubmed: 26985032
Elife. 2016 May 23;5:
pubmed: 27213521