Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton.
actin
cytoskeleton
metals in medicine
plectin
tubulin
vimentin
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
revised:
21
06
2023
received:
03
03
2023
medline:
4
9
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
During recent years, accumulating evidence suggested that metal-based candidate drugs are promising modulators of cytoskeletal and cytoskeleton-associated proteins. This was substantiated by the identification and validation of actin, vimentin and plectin as targets of distinct ruthenium(II)- and platinum(II)-based modulators. Despite this, structural information about molecular interaction is scarcely available. Here, we compile the scattered reports about metal-based candidate molecules that influence the cytoskeleton, its associated proteins and explore their potential to interfere in cancer-related processes, including proliferation, invasion and the epithelial-to-mesenchymal transition. Advances in this field depend crucially on determining binding sites and on gaining comprehensive insight into molecular drug-target interactions. These are key steps towards establishing yet elusive structure-activity relationships.
Identifiants
pubmed: 37345897
doi: 10.1002/cbic.202300178
doi:
Substances chimiques
Actins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300178Subventions
Organisme : Austrian Science Fund FWF
ID : P33238-N
Pays : Austria
Informations de copyright
© 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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