Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook.


Journal

American journal of respiratory and critical care medicine
ISSN: 1535-4970
Titre abrégé: Am J Respir Crit Care Med
Pays: United States
ID NLM: 9421642

Informations de publication

Date de publication:
15 08 2023
Historique:
medline: 16 8 2023
pubmed: 22 6 2023
entrez: 22 6 2023
Statut: ppublish

Résumé

Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive inflammatory airway disease associated with a significant impact on patients' lives, including morbidity and mortality, and significant healthcare costs. Current pharmacologic strategies, including first- and second-line therapies such as long-acting β

Identifiants

pubmed: 37348121
doi: 10.1164/rccm.202303-0455CI
doi:

Substances chimiques

Alarmins 0
Biological Products 0
Adrenergic beta-2 Receptor Agonists 0
Adrenal Cortex Hormones 0
Bronchodilator Agents 0

Types de publication

Video-Audio Media Review Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

395-405

Subventions

Organisme : Department of Health
Pays : United Kingdom

Auteurs

Klaus F Rabe (KF)

LungenClinic Grosshansdorf, Grosshansdorf, Germany.
Christian Albrechts University of Kiel, Kiel, Germany.
Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.

Stephen Rennard (S)

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

Fernando J Martinez (FJ)

NewYork-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.

Bartolome R Celli (BR)

Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Dave Singh (D)

Medicines Evaluation Unit, Manchester University National Health Service Foundation Trust, University of Manchester, Manchester, United Kingdom.

Alberto Papi (A)

Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Mona Bafadhel (M)

School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Jigna Heble (J)

Sanofi, Bridgewater, New Jersey; and.

Amr Radwan (A)

Regeneron Pharmaceuticals Inc., Tarrytown, New York.

Xavier Soler (X)

Regeneron Pharmaceuticals Inc., Tarrytown, New York.

Juby A Jacob Nara (JA)

Sanofi, Bridgewater, New Jersey; and.

Yamo Deniz (Y)

Regeneron Pharmaceuticals Inc., Tarrytown, New York.

Paul J Rowe (PJ)

Sanofi, Bridgewater, New Jersey; and.

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Classifications MeSH