Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
05 07 2023
05 07 2023
Historique:
medline:
6
7
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
We report a new computational protein design method for the construction of oligomeric protein assemblies around metal centers with predefined coordination geometries. We apply this method to design two homotrimeric assemblies, Tet4 and TP1, with tetrahedral and trigonal-pyramidal tris(histidine) metal coordination geometries, respectively, and demonstrate that both assemblies form the targeted metal centers with ≤0.2 Å accuracy. Although Tet4 and TP1 are constructed from the same parent protein building block, they are distinct in terms of their overall architectures, the environment surrounding the metal centers, and their metal-based reactivities, illustrating the versatility of our approach.
Identifiants
pubmed: 37352018
doi: 10.1021/jacs.3c04047
pmc: PMC10439731
mid: NIHMS1922214
doi:
Substances chimiques
Metalloproteins
0
Metals
0
Histidine
4QD397987E
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14208-14214Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM138884
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124169
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008326
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM133894
Pays : United States
Organisme : NIH HHS
ID : S10 OD026941
Pays : United States
Références
J Am Chem Soc. 2013 Sep 11;135(36):13393-9
pubmed: 23924187
Biochemistry. 2015 Jul 14;54(27):4167-80
pubmed: 26079379
J Biol Inorg Chem. 2008 Nov;13(8):1205-18
pubmed: 18604568
Nat Chem. 2021 Apr;13(4):312-318
pubmed: 33603222
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6298-305
pubmed: 10841536
Nat Chem. 2014 Mar;6(3):236-41
pubmed: 24557139
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11922-7
pubmed: 11050226
Photosynth Res. 1993 Aug;37(2):103-16
pubmed: 24317707
Chem Commun (Camb). 2022 Jun 16;58(49):6958-6961
pubmed: 35642584
Chem Rev. 2014 Jan 8;114(1):538-56
pubmed: 24040963
J Am Chem Soc. 2020 Mar 18;142(11):5338-5354
pubmed: 32062969
Nat Rev Microbiol. 2009 Jan;7(1):25-35
pubmed: 19079350
Acc Chem Res. 2010 May 18;43(5):661-72
pubmed: 20192262
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30362-30369
pubmed: 33203677
J Am Chem Soc. 2018 Sep 12;140(36):11210-11213
pubmed: 30141918
Annu Rev Biochem. 1970;39:977-1042
pubmed: 4320264
Protein Sci. 2006 Dec;15(12):2785-94
pubmed: 17132862
Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6430-4
pubmed: 23640811
Nat Rev Chem. 2022 Jan;6(1):31-50
pubmed: 35811759
Biochemistry. 2022 Oct 4;61(19):2063-2072
pubmed: 36106943
Annu Rev Biochem. 1996;65:537-61
pubmed: 8811189
Science. 1988 May 27;240(4856):1177-81
pubmed: 2453923
Nat Chem Biol. 2009 Dec;5(12):882-4
pubmed: 19915535
Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4570-4590
pubmed: 12404359
Nature. 2009 Aug 13;460(7257):855-62
pubmed: 19675646
Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14
pubmed: 11994741
Nat Chem. 2011 Nov 27;4(2):118-23
pubmed: 22270627
Essays Biochem. 2017 May 9;61(2):245-258
pubmed: 28487401
Acc Chem Res. 2019 Feb 19;52(2):345-355
pubmed: 30698941
Proteins. 1995 Oct;23(2):256-63
pubmed: 8592706
Chem Rev. 2014 Apr 9;114(7):3659-853
pubmed: 24588098
Biochemistry. 2021 Feb 16;60(6):431-439
pubmed: 33533248
Protein Sci. 2017 Aug;26(8):1584-1594
pubmed: 28513090
J Am Chem Soc. 2013 Aug 14;135(32):12013-22
pubmed: 23905754
Methods Enzymol. 2011;487:545-74
pubmed: 21187238
J Am Chem Soc. 2007 Nov 7;129(44):13374-5
pubmed: 17929927
Nat Chem Biol. 2015 Oct;11(10):744-7
pubmed: 26379012
Nat Chem. 2019 May;11(5):434-441
pubmed: 30778140
J Am Chem Soc. 2005 Apr 27;127(16):5804-5
pubmed: 15839675
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21234-9
pubmed: 23236170
Biochemistry. 2005 Aug 9;44(31):10732-40
pubmed: 16060682
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6191-6196
pubmed: 28566494
Chem Rev. 2014 Apr 9;114(7):3369-80
pubmed: 24279515
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11566-70
pubmed: 15292507
J Am Chem Soc. 2016 Oct 12;138(40):13163-13166
pubmed: 27649076
Science. 1999 Jun 4;284(5420):1667-70
pubmed: 10356396
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
J Am Chem Soc. 2012 Jan 11;134(1):375-85
pubmed: 22092237
Chem Rev. 2014 Apr 9;114(7):3495-578
pubmed: 24661096
J Am Chem Soc. 2002 Jun 19;124(24):6826-7
pubmed: 12059194
Science. 2022 Oct 7;378(6615):49-56
pubmed: 36108050
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):21940-21944
pubmed: 32830423
Science. 1994 Jan 21;263(5145):375-7
pubmed: 8278810
Proteins. 1988;4(4):274-82
pubmed: 3151019
Nat Chem. 2012 Nov;4(11):900-6
pubmed: 23089864
Science. 2022 Jul 22;377(6604):387-394
pubmed: 35862514
Science. 2014 Dec 19;346(6216):1525-8
pubmed: 25525249
J Mol Biol. 1991 Dec 5;222(3):763-85
pubmed: 1749000
J Am Chem Soc. 2010 Jun 30;132(25):8610-7
pubmed: 20515031
J Biol Chem. 2001 Dec 28;276(52):48615-8
pubmed: 11696553
J Am Chem Soc. 2022 Oct 5;144(39):18090-18100
pubmed: 36154053
J Am Chem Soc. 2013 Dec 4;135(48):18096-107
pubmed: 24182361
Nature. 2022 Mar;603(7901):522-527
pubmed: 35236987
Annu Rev Biophys. 2008;37:97-116
pubmed: 18573074
Nat Chem. 2021 Jul;13(7):643-650
pubmed: 33972753
Inorg Chem. 2009 Apr 6;48(7):2726-8
pubmed: 19267481
Nat Struct Biol. 2003 Feb;10(2):98-103
pubmed: 12524531
Chem Rev. 2018 Jan 10;118(1):142-231
pubmed: 28714313
Nat Commun. 2017 Aug 25;8(1):358
pubmed: 28842561
Nucleic Acids Res. 2018 Jan 4;46(D1):D459-D464
pubmed: 29077942
Chem Rev. 1996 Nov 7;96(7):2239-2314
pubmed: 11848828
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15041-6
pubmed: 8986760
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14231-6
pubmed: 9405595
Nat Chem. 2017 May;9(5):411-419
pubmed: 28430192
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15012-15017
pubmed: 27940918
Proc Natl Acad Sci U S A. 1968 Feb;59(2):498-505
pubmed: 5238980
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3589-94
pubmed: 12598659
ACS Cent Sci. 2019 Jul 24;5(7):1120-1136
pubmed: 31404244
Nature. 2009 Aug 13;460(7257):823-30
pubmed: 19675642