Insight on the Intracellular Supramolecular Assembly of DTTO: A Peculiar Example of Cell-Driven Polymorphism.
biomaterials
electroactive fibers
polymorphs
supramolecular assembly
thiophene
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
07
06
2023
received:
24
03
2023
medline:
23
10
2023
pubmed:
27
6
2023
entrez:
26
6
2023
Statut:
ppublish
Résumé
The assembly of supramolecular structures within living systems is an innovative approach for introducing artificial constructs and developing biomaterials capable of influencing and/or regulating the biological responses of living organisms. By integrating chemical, photophysical, morphological, and structural characterizations, it is shown that the cell-driven assembly of 2,6-diphenyl-3,5-dimethyl-dithieno[3,2-b:2',3'-d]thiophene-4,4-dioxide (DTTO) molecules into fibers results in the formation of a "biologically assisted" polymorphic form, hence the term bio-polymorph. Indeed, X-ray diffraction reveals that cell-grown DTTO fibers present a unique molecular packing leading to specific morphological, optical, and electrical properties. Monitoring the process of fiber formation in cells with time-resolved photoluminescence, it is established that cellular machinery is necessary for fiber production and a non-classical nucleation mechanism for their growth is postulated. These biomaterials may have disruptive applications in the stimulation and sense of living cells, but more crucially, the study of their genesis and properties broadens the understanding of life beyond the native components of cells.
Identifiants
pubmed: 37364565
doi: 10.1002/adma.202302756
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302756Informations de copyright
© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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