Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 06 2023
26 06 2023
Historique:
received:
30
08
2022
accepted:
07
06
2023
medline:
28
6
2023
pubmed:
27
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear how membrane potentials of individual neurons track behavioral rhythms, even though many neurons exhibit pace-making properties in isolated brain circuits. To examine whether single-cell voltage rhythmicity is coupled to behavioral rhythms, we focused on delta-frequencies (1-4 Hz) that are known to occur at both the neural network and behavioral levels. We performed membrane voltage imaging of individual striatal neurons simultaneously with network-level local field potential recordings in mice during voluntary movement. We report sustained delta oscillations in the membrane potentials of many striatal neurons, particularly cholinergic interneurons, which organize spikes and network oscillations at beta-frequencies (20-40 Hz) associated with locomotion. Furthermore, the delta-frequency patterned cellular dynamics are coupled to animals' stepping cycles. Thus, delta-rhythmic cellular dynamics in cholinergic interneurons, known for their autonomous pace-making capabilities, play an important role in regulating network rhythmicity and movement patterning.
Identifiants
pubmed: 37365189
doi: 10.1038/s41467-023-39497-z
pii: 10.1038/s41467-023-39497-z
pmc: PMC10293266
doi:
Substances chimiques
Cholinergic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3802Subventions
Organisme : NIH HHS
ID : S10 OD024993
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115797
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122971
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS115421
Pays : United States
Informations de copyright
© 2023. The Author(s).
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