Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare.

Antidotes / metabolism Bacterial Proteins / genetics Type VI Secretion Systems / genetics Enterobacter cloacae Biological Warfare
Gram-negative bacteria bacterial antagonism immunity proteins type VI secretion system

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
27 06 2023
Historique:
medline: 29 6 2023
pubmed: 27 6 2023
entrez: 27 6 2023
Statut: ppublish

Résumé

S.J. Jensen, Z.C. Ruhe, A.F. Williams, D.Q. Nhan, et al. (J Bacteriol 205:e00113-23, 2023, https://doi.org/10.1128/jb.00113-23) demonstrate that a type VI secretion system (T6SS) immunity protein, Tli, functions to both neutralize and activate its cognate toxin, Tle, in Enterobacter cloacae. Their results reveal the surprising finding that Tli function differs, depending on its subcellular localization. Overall, this study enhances our understanding of T6SS immunity proteins, which are commonly viewed as monofunctional toxin-neutralizing antidotes.

Identifiants

DOI: 10.1128/jb.00161-23 PMID: 37366633 PMC: PMC10294624
pubmed: 37366633
doi: 10.1128/jb.00161-23
pmc: PMC10294624
doi:

Substances chimiques

Antidotes 0
Bacterial Proteins 0
Type VI Secretion Systems 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0016123

Commentaires et corrections

Type : CommentOn

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Shehryar Ahmad (S)

Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-2747-5212

John C Whitney (JC)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario Canada.
Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
ORCID: 0000-0002-4423-658X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antidotes › Location, Location, Location: an Antidote That...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Location, Location, Location: an Antidote That...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type VI › Location, Location, Location: an Antidote That...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Enterobacter › Enterobacter cloacae › Location, Location, Location: an Antidote That...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Guerre et conflits armés › Guerre › Guerre biologique › Location, Location, Location: an Antidote That...