Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation.
endothelial cells
ischemia-reperfusion injury
machine perfusion
mitochondria
reactive oxygen species
shears stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jun 2023
13 Jun 2023
Historique:
received:
16
04
2023
revised:
30
05
2023
accepted:
02
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular crosstalk, vascular homeostasis, and blood fluidity. Comparable to other cells, their metabolic function strongly depends on mitochondrial health, and the response to flow changes observed in endothelial cells is linked to their mitochondrial metabolism. Despite the direct impact of new dynamic preservation concepts in organ transplantation, the impact of different perfusion conditions on sinusoidal endothelial cells is not yet explored well enough. This article therefore describes the key role of liver sinusoidal endothelial cells (LSECs) together with their mitochondrial function in the context of liver transplantation. The currently available ex situ machine perfusion strategies are described with their effect on LSEC health. Specific perfusion conditions, including perfusion pressure, duration, and perfusate oxygenation are critically discussed considering the metabolic function and integrity of liver endothelial cells and their mitochondria.
Identifiants
pubmed: 37373238
pii: ijms241210091
doi: 10.3390/ijms241210091
pmc: PMC10298511
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Cell Biol. 2022 Jul 4;221(7):
pubmed: 35695893
J Biol Chem. 2003 Sep 26;278(39):36989-92
pubmed: 12912994
Nat Biotechnol. 2022 Nov;40(11):1610-1616
pubmed: 35641829
Cell Tissue Res. 2020 Aug;381(2):239-254
pubmed: 32347385
Circulation. 2010 May 11;121(18):2012-22
pubmed: 20421521
J Heart Lung Transplant. 2015 Nov;34(11):1471-80
pubmed: 26140808
J Hepatol. 2017 Jan;66(1):212-227
pubmed: 27423426
Liver Transpl. 2016 Mar;22(3):333-43
pubmed: 26439190
Ann Surg. 2022 Jun 1;275(6):1156-1164
pubmed: 35258511
Transplantation. 2023 Jun 1;107(6):1286-1290
pubmed: 36922379
Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33660-33667
pubmed: 33318210
JHEP Rep. 2020 Oct 09;3(1):100194
pubmed: 33305200
Cell Res. 2009 Jul;19(7):802-15
pubmed: 19532122
J Hepatol. 2022 Jun;76(6):1330-1347
pubmed: 35589254
Cryobiology. 2004 Jun;48(3):322-32
pubmed: 15157780
Transplantation. 2018 Apr;102(4):e147-e154
pubmed: 29309377
PLoS One. 2019 Oct 23;14(10):e0224066
pubmed: 31644544
Gastroenterology. 2008 May;134(6):1641-54
pubmed: 18471544
World J Gastroenterol. 2022 May 21;28(19):2100-2111
pubmed: 35664031
Ann Biomed Eng. 2004 Apr;32(4):623-31
pubmed: 15117035
JHEP Rep. 2020 Feb 17;2(2):100092
pubmed: 32195456
Hepatology. 1994 Jul;20(1 Pt 1):177-85
pubmed: 7517381
Blood. 2002 Sep 1;100(5):1689-98
pubmed: 12176889
JCI Insight. 2018 Aug 9;3(15):
pubmed: 30089724
Sci Transl Med. 2021 Sep 15;13(611):eabf7601
pubmed: 34524862
Front Physiol. 2020 Aug 28;11:990
pubmed: 32982772
Sci Rep. 2015 Nov 09;5:16279
pubmed: 26549018
Function (Oxf). 2022 Dec 09;4(2):zqac063
pubmed: 36778749
Liver Transpl. 2018 Oct;24(10):1437-1452
pubmed: 30040176
Curr Opin Organ Transplant. 2017 Dec;22(6):563-570
pubmed: 28922301
Liver Int. 2009 Apr;29(4):603-13
pubmed: 18662275
J Hepatol. 2023 May;78(5):1007-1016
pubmed: 36740047
JAMA Surg. 2022 Mar 01;157(3):189-198
pubmed: 34985503
Nihon Geka Hokan. 1993 Mar 1;62(2):58-70
pubmed: 8239863
Nat Commun. 2020 Jun 16;11(1):2939
pubmed: 32546694
Free Radic Biol Med. 2018 Aug 20;124:517-524
pubmed: 30037775
Biology (Basel). 2022 Sep 08;11(9):
pubmed: 36138808
Transpl Int. 2007 Apr;20(4):343-52
pubmed: 17326775
Nat Commun. 2021 Jan 29;12(1):681
pubmed: 33514719
Artif Organs. 2022 Dec;46(12):2504-2510
pubmed: 35929443
Mol Cell Biol. 2005 Oct;25(19):8553-66
pubmed: 16166637
Transpl Int. 2021 Feb;34(2):353-364
pubmed: 33275807
J Clin Invest. 2006 Jan;116(1):49-58
pubmed: 16341264
Transplant Direct. 2021 Aug 05;7(9):e741
pubmed: 34386578
Transpl Int. 2010 Sep;23(9):944-50
pubmed: 20210932
Nat Biotechnol. 2020 Feb;38(2):189-198
pubmed: 31932726
Transplantation. 2003 Aug 15;76(3):501-8
pubmed: 12923435
PLoS One. 2019 Aug 6;14(8):e0220786
pubmed: 31386697
Dev Cell. 2015 Jan 12;32(1):82-96
pubmed: 25584796
Circ Res. 2016 Mar 4;118(5):898-906
pubmed: 26941425
J Pineal Res. 2019 Mar;66(2):e12542
pubmed: 30516280
Sci Rep. 2016 Mar 03;6:22415
pubmed: 26935866
Nat Immunol. 2017 Apr 18;18(5):488-498
pubmed: 28418387
Transplant Direct. 2021 Dec 16;8(1):e1265
pubmed: 34934807
Transplant Proc. 2016 May;48(4):1239-43
pubmed: 27320595
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):499-508
pubmed: 24526695
Dev Cell. 2006 Dec;11(6):845-57
pubmed: 17141159
Nature. 2002 Nov 7;420(6911):27
pubmed: 12422197
Cell Res. 2011 Apr;21(4):558-60
pubmed: 21283134
Ann Surg. 2021 Nov 1;274(5):705-712
pubmed: 34334635
Sci Rep. 2020 Dec 1;10(1):20966
pubmed: 33262362
Int J Mol Sci. 2020 Apr 29;21(9):
pubmed: 32365506
Am J Transplant. 2022 Jul;22(7):1842-1851
pubmed: 35315202
Int J Mol Sci. 2022 Aug 28;23(17):
pubmed: 36077144
J Hepatol. 2014 Dec;61(6):1267-75
pubmed: 25086285
Physiol Rev. 2018 Jan 1;98(1):3-58
pubmed: 29167330
J Hepatol. 2023 Apr;78(4):783-793
pubmed: 36681160
Theranostics. 2021 Apr 19;11(13):6461-6476
pubmed: 33995668
Transplant Res. 2012 May 09;1(1):6
pubmed: 23369351
Eur J Histochem. 2011 Nov 18;55(4):e40
pubmed: 22297446
Mol Metab. 2020 Feb;32:122-135
pubmed: 32029222
Transplantation. 2013 Sep;96(6):538-42
pubmed: 23823654
HPB (Oxford). 2017 Jun;19(6):538-546
pubmed: 28351756
Transplantation. 2023 May 1;107(5):e125-e126
pubmed: 36857151
J Exp Biol. 2002 Jul;205(Pt 13):1831-41
pubmed: 12077159
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Hepatology. 2007 Sep;46(3):871-84
pubmed: 17680646
Am J Transplant. 2013 May;13(5):1327-35
pubmed: 23463950
Liver Transpl. 2016 Jan;22(1):111-9
pubmed: 26390093
Liver Transpl. 2022 Oct;28(10):1678-1680
pubmed: 35607708
Mol Immunol. 2018 Nov;103:115-124
pubmed: 30248487
JAMA. 1999 Dec 1;282(21):2035-42
pubmed: 10591386
Liver Transpl. 2016 Nov;22(11):1573-1583
pubmed: 27556578
Liver Transpl. 2009 Jan;15(1):20-9
pubmed: 19109848
Exp Cell Res. 2013 Oct 15;319(17):2501-13
pubmed: 23792081
Liver Transpl. 2014 Nov;20(11):1296-305
pubmed: 25179693
EBioMedicine. 2020 Oct;60:103014
pubmed: 32979838
Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):171-179
pubmed: 28624105
J Surg Res. 2020 Jan;245:410-419
pubmed: 31437648
Am J Transplant. 2012 Sep;12(9):2477-86
pubmed: 22594953
Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):79-89
pubmed: 23229329
Artif Organs. 2022 Feb;46(2):306-311
pubmed: 34724239
Am J Transplant. 2022 Oct;22(10):2401-2408
pubmed: 35671067
J Leukoc Biol. 2006 Jun;79(6):1295-305
pubmed: 16551680
Am J Transplant. 2016 Mar;16(3):794-807
pubmed: 26663737
Transplantation. 2011 Jan 15;91(1):42-7
pubmed: 21441852
Nature. 2018 May;557(7703):50-56
pubmed: 29670285
Transplant Proc. 2015 Mar;47(2):419-26
pubmed: 25769584
MAGMA. 2012 Oct;25(5):391-9
pubmed: 22644411
J Hepatol. 2017 Jan;66(1):86-94
pubmed: 27545498
BMJ Open Gastroenterol. 2022 Jan;9(1):
pubmed: 35039326
Am J Transplant. 2017 May;17(5):1204-1215
pubmed: 27860296
Transplantation. 2023 Feb 1;107(2):326-340
pubmed: 35939388
Liver Transpl. 2016 Jul;22(7):968-78
pubmed: 27037634
Transplantation. 2019 Oct;103(10):2057-2064
pubmed: 30951018
Am J Transplant. 2014 Jun;14(6):1400-9
pubmed: 24758155
Ann Surg. 2021 Nov 1;274(5):836-842
pubmed: 34334640
J Hepatol. 2017 Sep 21;:
pubmed: 28870676
Cell Metab. 2016 Feb 9;23(2):254-63
pubmed: 26777689
Circ Res. 2007 Apr 27;100(8):1128-41
pubmed: 17463328
Am J Transplant. 2022 May;22(5):1382-1395
pubmed: 35150050
Exp Gerontol. 2023 Apr;174:112134
pubmed: 36849000
Elife. 2017 May 30;6:
pubmed: 28556776
PLoS One. 2014 Feb 14;9(2):e88521
pubmed: 24551114
J Hepatol. 2013 Feb;58(2):278-86
pubmed: 23063573
J Hepatol. 2013 Nov;59(5):1094-106
pubmed: 23811302
N Engl J Med. 2021 Apr 15;384(15):1391-1401
pubmed: 33626248
Nature. 2010 Mar 4;464(7285):104-7
pubmed: 20203610
JCI Insight. 2022 Sep 22;7(18):
pubmed: 36134656
Ann Surg. 2011 Dec;254(6):1000-7
pubmed: 21862925
J Transplant. 2013;2013:802618
pubmed: 24222842
J Am Soc Nephrol. 2020 Jan;31(1):118-138
pubmed: 31818909