Claustral neurons projecting to frontal cortex restrict opioid consumption.

Mice Humans Animals Claustrum / physiology Analgesics, Opioid / pharmacology Basal Ganglia / physiology Frontal Lobe Neurons / physiology Fentanyl / pharmacology Opioid-Related Disorders
anterior cingulate cortex claustrum conditioned-place preference constitutive silencing fentanyl home-cage behavior neuropixels opioids optogenetics orbitofrontal cortex photometry self-administration transcriptomics

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
10 07 2023
Historique:
received: 20 10 2022
revised: 13 04 2023
accepted: 26 05 2023
medline: 13 7 2023
pubmed: 29 6 2023
entrez: 28 6 2023
Statut: ppublish

Résumé

The synthetic opioid fentanyl is a major contributor to the current opioid addiction crisis. We report that claustral neurons projecting to the frontal cortex limit oral fentanyl self-administration in mice. We found that fentanyl transcriptionally activates frontal-projecting claustrum neurons. These neurons also exhibit a unique suppression of Ca

Identifiants

DOI: 10.1016/j.cub.2023.05.065 PMID: 37379841 PMC: PMC10357322
pubmed: 37379841
pii: S0960-9822(23)00737-6
doi: 10.1016/j.cub.2023.05.065
pmc: PMC10357322
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Fentanyl UF599785JZ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2761-2773.e8

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

Cell Rep. 2018 Jan 2;22(1):84-95
pubmed: 29298436
Curr Biol. 2018 Sep 10;28(17):R937-R939
pubmed: 30205064
J Neurosci. 2020 Nov 11;40(46):8853-8869
pubmed: 33046548
Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8126-8134
pubmed: 32205443
Elife. 2018 Oct 30;7:
pubmed: 30373717
J Comp Neurol. 2018 Oct 15;526(15):2428-2443
pubmed: 30252130
Psychopharmacology (Berl). 1985;86(1-2):37-42
pubmed: 2991967
Br J Anaesth. 2020 Jan;124(1):44-62
pubmed: 31653394
JAMA Psychiatry. 2013 Jul;70(7):661-3
pubmed: 23636789
J Pharmacol Exp Ther. 2011 Nov;339(2):438-50
pubmed: 21841040
Front Syst Neurosci. 2014 Jul 02;8:117
pubmed: 25071474
Front Neural Circuits. 2021 May 13;15:658228
pubmed: 34054437
Nat Rev Neurosci. 2011 Oct 05;12(11):685-700
pubmed: 21971065
Neuropsychopharmacology. 2016 Jan;41(1):335-56
pubmed: 25976297
Brain Res. 2010 Feb 16;1314:44-55
pubmed: 19716811
Philos Trans R Soc Lond B Biol Sci. 2019 Feb 18;374(1766):20180145
pubmed: 30966923
Psychopharmacology (Berl). 2016 Jul;233(13):2479-87
pubmed: 27117141
Trends Cogn Sci. 2019 Mar;23(3):213-234
pubmed: 30711326
Psychopharmacology (Berl). 2009 Apr;203(3):561-70
pubmed: 19005643
Curr Biol. 2020 Sep 21;30(18):R1038-R1040
pubmed: 32961157
Anesthesiology. 1985 Mar;62(3):234-41
pubmed: 3919613
Curr Opin Neurobiol. 2013 Aug;23(4):473-9
pubmed: 23453713
eNeuro. 2020 Jul 23;7(4):
pubmed: 32561573
Neurosci Biobehav Rev. 2019 Nov;106:49-57
pubmed: 30528374
Nat Commun. 2019 Apr 4;10(1):1536
pubmed: 30948727
Front Neuroinform. 2015 Apr 08;9:7
pubmed: 25904861
Nat Rev Neurosci. 2011 Oct 20;12(11):652-69
pubmed: 22011681
Cell Rep. 2023 Feb 11;42(2):112118
pubmed: 36774552
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Neuron. 2018 Sep 5;99(5):1029-1039.e4
pubmed: 30122374
Neuroimage. 2006 Jun;31(2):661-9
pubmed: 16459107
Curr Biol. 2020 Sep 21;30(18):3522-3532.e6
pubmed: 32707061
Nat Rev Neurosci. 2016 Sep;17(9):592-9
pubmed: 27277868
Psychopharmacology (Berl). 2021 Mar;238(3):699-710
pubmed: 33226446
J Neurosci. 2020 Mar 18;40(12):2485-2497
pubmed: 32051327
Nat Methods. 2017 Oct;14(10):955-958
pubmed: 28846088
Addict Biol. 2020 Nov;25(6):e12845
pubmed: 31696597
Nat Neurosci. 2020 Jun;23(6):741-753
pubmed: 32393895
Ann N Y Acad Sci. 2014 Oct;1327:1-26
pubmed: 24654857
Pharmacol Biochem Behav. 2018 Jan;164:106-117
pubmed: 28778737
J Neurosci. 2021 Aug 18;41(33):7048-7064
pubmed: 34244361
Neuropsychol Rev. 2007 Sep;17(3):337-45
pubmed: 17680368
Neuromodulation. 2020 Oct 9;:
pubmed: 33090660
Neuropsychopharmacol Rep. 2019 Mar;39(1):17-35
pubmed: 30506634
Sci Adv. 2020 Aug 05;6(32):eabc0413
pubmed: 32821843
Neuron. 2022 Feb 2;110(3):486-501.e7
pubmed: 34863367
Bioinformatics. 2011 Apr 15;27(8):1179-80
pubmed: 21349861
Curr Biol. 2018 Sep 10;28(17):2752-2762.e7
pubmed: 30122531
Anesth Analg. 1996 Jun;82(6):1247-51
pubmed: 8638799
Cogn Affect Behav Neurosci. 2019 Jun;19(3):435-458
pubmed: 30963411
Neuroscience. 2015 Jan 22;284:107-124
pubmed: 25290009
Drug Alcohol Depend. 2021 Jan 1;218:108350
pubmed: 33121867
Psychopharmacology (Berl). 2010 Jun;210(2):121-35
pubmed: 20352414
Cogn Affect Behav Neurosci. 2012 Jun;12(2):241-68
pubmed: 22282036
Ann N Y Acad Sci. 1992 Jun 28;654:254-73
pubmed: 1321572
J Neurosci. 2019 Dec 11;39(50):10071-10080
pubmed: 31704786
JAMA Psychiatry. 2021 Jun 1;78(6):585-586
pubmed: 33377967
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23304-23310
pubmed: 31636216
Curr Biol. 2020 Jul 20;30(14):2777-2790.e4
pubmed: 32531275
Neuropsychopharmacology. 2014 Dec;39(13):2919-27
pubmed: 24947901
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19556-19565
pubmed: 32694207

Auteurs

Anna Terem (A)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Yonatan Fatal (Y)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Noa Peretz-Rivlin (N)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Hagit Turm (H)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Shahar Shohat Koren (SS)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Danny Kitsberg (D)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Reut Ashwal-Fluss (R)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Diptendu Mukherjee (D)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Naomi Habib (N)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Ami Citri (A)

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel; Institute of Life Sciences, Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel; Program in Child and Brain Development, Canadian Institute for Advanced Research, MaRS Centre, West Tower, 661 University Avenue, Suite 505, Toronto, ON M5G 1M1, Canada. Electronic address: ami.citri@mail.huji.ac.il.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Eucaryotes › Animaux › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Claustrum › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Cellules › Neurones › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › Claustral neurons projecting to frontal cortex...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'usage de substances psychotropes › Troubles liés aux opiacés › Claustral neurons projecting to frontal cortex...