Ang II Promotes ET-1 Production by Regulating NOX2 Activity Through Transcription Factor Oct-1.

Mice Animals Humans Superoxides / metabolism Endothelial Cells / metabolism Octamer Transcription Factor-1 NADPH Oxidases / genetics Angiotensin II / pharmacology Reactive Oxygen Species / metabolism
NADPH oxidases angiotensin II endothelial cells endothelin 1 reactive oxygen species

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
08 2023
Historique:
medline: 28 7 2023
pubmed: 29 6 2023
entrez: 29 6 2023
Statut: ppublish

Résumé

Increasing evidence suggests that superoxide ions produced by NOX (nicotinamide adenine dinucleotide phosphate oxidases) mediate vascular effects of Ang II (angiotensin II) evoked by atherogenic diets. Here, we analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 (endothelin 1) production in human microvascular endothelial cells. The effects of high-fat diet were compared between WT (wild type) and Feeding mice high-fat diet for 10 weeks increased cardiac expression and plasma levels of Ang II and ET-1 in WT but not in Ang II may promote ET-1 production in the endothelium in response to atherogenic diets through a mechanism that involves the transcription factor Oct-1 and the increased formation of superoxide anions by NOX2.

Sections du résumé

BACKGROUND
Increasing evidence suggests that superoxide ions produced by NOX (nicotinamide adenine dinucleotide phosphate oxidases) mediate vascular effects of Ang II (angiotensin II) evoked by atherogenic diets. Here, we analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 (endothelin 1) production in human microvascular endothelial cells.
METHODS
The effects of high-fat diet were compared between WT (wild type) and
RESULTS
Feeding mice high-fat diet for 10 weeks increased cardiac expression and plasma levels of Ang II and ET-1 in WT but not in
CONCLUSIONS
Ang II may promote ET-1 production in the endothelium in response to atherogenic diets through a mechanism that involves the transcription factor Oct-1 and the increased formation of superoxide anions by NOX2.

Identifiants

DOI: 10.1161/ATVBAHA.122.318764 PMID: 37381986
pubmed: 37381986
doi: 10.1161/ATVBAHA.122.318764
doi:

Substances chimiques

Superoxides 11062-77-4
Octamer Transcription Factor-1 0
NADPH Oxidases EC 1.6.3.-
Angiotensin II 11128-99-7
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1429-1440

Auteurs

Julian Kamhieh-Milz (J)

Institute of Transfusion Medicine (J.K.-M.), Charité Universitätsmedizin Berlin, Germany.

Lei Chen (L)

Department of Nephrology and Medical Intensive Care (L.C., G. Moll, R.C.), Charité Universitätsmedizin Berlin, Germany.
Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China (L.C.).

Claudia Goettsch (C)

Division of Vascular Endothelium and Microcirculation, Department of Medicine III (C.G., A.H., C.B., G.G.M., H.M.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
Department of Internal Medicine I-Cardiology, Medical Faculty, RWTH Aachen University, Germany (C.G.).
ORCID: 0000-0002-7973-1329

Anna Maria Pfefferkorn (AM)

Department of General, Visceral and Transplantation Surgery (A.M.P., M.I.A.), Charité Universitätsmedizin Berlin, Germany.
ORCID: 0000-0002-7126-9838

Anja Hofmann (A)

Division of Vascular Endothelium and Microcirculation, Department of Medicine III (C.G., A.H., C.B., G.G.M., H.M.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery (A.H.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
ORCID: 0000-0002-1490-6474

Coy Brunssen (C)

Division of Vascular Endothelium and Microcirculation, Department of Medicine III (C.G., A.H., C.B., G.G.M., H.M.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
ORCID: 0000-0002-6421-9752

Gregor M Müller (GM)

Division of Vascular Endothelium and Microcirculation, Department of Medicine III (C.G., A.H., C.B., G.G.M., H.M.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.

Thomas Walther (T)

Department of Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork, Ireland (T.W.).
Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Germany (T.W.).
ORCID: 0000-0002-6725-4473

Muhammad Imtiaz Ashraf (MI)

Department of General, Visceral and Transplantation Surgery (A.M.P., M.I.A.), Charité Universitätsmedizin Berlin, Germany.

Guido Moll (G)

Department of Nephrology and Medical Intensive Care (L.C., G. Moll, R.C.), Charité Universitätsmedizin Berlin, Germany.
ORCID: 0000-0001-6173-5957

Henning Morawietz (H)

Division of Vascular Endothelium and Microcirculation, Department of Medicine III (C.G., A.H., C.B., G.G.M., H.M.), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
ORCID: 0000-0001-9360-9736

Janusz Witowski (J)

Department of Pathophysiology, Poznan University of Medical Sciences, Poland (J.W.).
ORCID: 0000-0002-1093-6027

Rusan Catar (R)

Department of Nephrology and Medical Intensive Care (L.C., G. Moll, R.C.), Charité Universitätsmedizin Berlin, Germany.
Berlin Institute of Health, Germany (R.C.).
ORCID: 0000-0002-7000-7860

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Eucaryotes › Animaux › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Superoxydes › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à domaine POU › Facteurs de transcription Oct › Facteur de transcription Oct-1 › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Ang II Promotes ET-1 Production by Regulating...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Ang II Promotes ET-1 Production by Regulating...