Propolis-loaded nanofiber scaffolds based on polyvinyl alcohol and polycaprolactone.
Cytotoxicity
Electrospinning
Morphology
Nanofibers
Propolis
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
11
10
2022
revised:
24
06
2023
accepted:
26
06
2023
medline:
24
7
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
ppublish
Résumé
Propolis-loaded electrospun nanofibers (PENs) have been regarded as promising candidates for biomedical purposes such as wound healing/dressing owing to their outstanding pharmacological and biological properties. This paper focuses on the development of electrospun nanofibers with optimum levels of propolis (PRP) and two polymer types (polycaprolactone (PCL) and polyvinyl alcohol (PVA)). Hence, response surface methodology (RSM) was employed to investigate the variation of the scaffold characteristics including porosity, average diameter, wettability, release, and tensile strength. For each response, a second-order polynomial model with a high coefficient of determination (R
Identifiants
pubmed: 37385356
pii: S0378-5173(23)00606-3
doi: 10.1016/j.ijpharm.2023.123186
pii:
doi:
Substances chimiques
polycaprolactone
24980-41-4
Polyvinyl Alcohol
9002-89-5
Propolis
9009-62-5
Polyesters
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123186Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.