β-Catenin regulates endocardial cushion growth by suppressing p21.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
15
05
2023
revised:
21
06
2023
accepted:
22
06
2023
medline:
3
7
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
Endocardial cushion formation is essential for heart valve development and heart chamber separation. Abnormal endocardial cushion formation often causes congenital heart defects. β-Catenin is known to be essential for endocardial cushion formation; however, the underlying cellular and molecular mechanisms remain incompletely understood. Here, we show that endothelial-specific deletion of β-catenin in mice resulted in formation of hypoplastic endocardial cushions due to reduced cell proliferation and impaired cell migration. By using a
Identifiants
pubmed: 37385754
pii: 6/9/e202302163
doi: 10.26508/lsa.202302163
pmc: PMC10310929
pii:
doi:
Substances chimiques
beta Catenin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133120
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148128
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL157347
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL159515
Pays : United States
Informations de copyright
© 2023 Liu et al.
Références
Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):526-34
pubmed: 21538813
Cell Mol Life Sci. 2013 Aug;70(16):2899-917
pubmed: 23161060
J Cell Biol. 2008 Jul 28;182(2):315-25
pubmed: 18663143
Nat Protoc. 2014 Aug;9(8):1931-43
pubmed: 25033209
Cell. 2002 Nov 27;111(5):673-85
pubmed: 12464179
Development. 2013 Aug;140(15):3176-87
pubmed: 23824573
Development. 2020 Jul 3;147(13):
pubmed: 32620577
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):543-552
pubmed: 27932350
Birth Defects Res C Embryo Today. 2011 Dec;93(4):298-311
pubmed: 22271679
Dev Biol. 2005 Feb 1;278(1):35-48
pubmed: 15649459
J Am Heart Assoc. 2012 Dec;1(6):e002261
pubmed: 23316316
Cardiovasc Res. 2017 Jan;113(1):40-51
pubmed: 28069701
Circ Res. 2006 Jun 9;98(11):1431-8
pubmed: 16645142
Front Cardiovasc Med. 2021 Jun 22;8:682298
pubmed: 34239905
Circ Res. 2009 Aug 28;105(5):408-21
pubmed: 19713546
Dev Cell. 2017 Nov 6;43(3):274-289.e5
pubmed: 29056552
Nature. 2003 Oct 9;425(6958):633-7
pubmed: 14534590
PLoS One. 2013;8(4):e60244
pubmed: 23560082
J Cell Biol. 2004 Aug 2;166(3):359-67
pubmed: 15289495
J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):33-36
pubmed: 24496676
Development. 2016 Mar 15;143(6):1041-54
pubmed: 26893350
Dev Cell. 2009 Jul;17(1):9-26
pubmed: 19619488
Cardiovasc Pathol. 2013 Mar-Apr;22(2):156-66
pubmed: 22889676
Genes Dev. 2011 Dec 15;25(24):2631-43
pubmed: 22190459
Genes Dev. 2004 Jan 1;18(1):99-115
pubmed: 14701881
J Cell Biol. 2006 Jan 2;172(1):151-62
pubmed: 16391003
Science. 2004 Oct 8;306(5694):247-52
pubmed: 15472070
Biochem Biophys Res Commun. 2003 Dec 12;312(2):380-7
pubmed: 14637149
Cardiovasc Res. 2017 Jan;113(1):6-9
pubmed: 28069697
Annu Rev Physiol. 2017 Feb 10;79:21-41
pubmed: 27959615
Circ Cardiovasc Genet. 2015 Jun;8(3):516-28
pubmed: 25814644
Mol Cell Biol. 2004 May;24(10):4241-54
pubmed: 15121845
Development. 2012 Sep;139(18):3277-99
pubmed: 22912411
Dev Biol. 2001 Feb 15;230(2):230-42
pubmed: 11161575
Curr Top Dev Biol. 2012;100:203-32
pubmed: 22449845
Circ Res. 2004 Sep 3;95(5):459-70
pubmed: 15345668
Circ Res. 2021 Apr 30;128(9):1330-1343
pubmed: 33914609
Annu Rev Physiol. 2011;73:29-46
pubmed: 20809794
PLoS One. 2010 Nov 30;5(11):e14127
pubmed: 21152425
Cardiovasc Pathol. 2011 May-Jun;20(3):162-7
pubmed: 20705485
J Mol Cell Cardiol. 2018 Oct;123:150-158
pubmed: 30201295
Dev Biol. 2010 Feb 15;338(2):127-35
pubmed: 19961844
Circ Res. 2010 Jul 23;107(2):186-99
pubmed: 20651295
Development. 2001 Apr;128(8):1253-64
pubmed: 11262227
BMC Cancer. 2013 Jan 09;13:12
pubmed: 23302090