Evaluation of methemoglobin as an intravascular contrast agent: T1 relaxation time effect in a rabbit model.
Animal model
Intravascular contrast
MR contrast agents
Methehomoglobin
Paramagnetic molecule
T1 relaxation
Journal
Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
15
05
2023
accepted:
28
06
2023
pmc-release:
01
11
2024
medline:
14
9
2023
pubmed:
2
7
2023
entrez:
1
7
2023
Statut:
ppublish
Résumé
Alternative contrast agents for MRI are needed for individuals who may respond adversely to gadolinium, and need an intravascular agent for specific indications. One potential contrast agent is intracellular methemoglobin, a paramagnetic molecule that is normally present in small amounts in red blood cells. An animal model was used to determine whether methemoglobin modulation with intravenous sodium nitrite transiently changes the T1 relaxation of blood. Four adult New Zealand white rabbits were treated with 30 mg intravenous sodium nitrite. 3D TOF and 3D MPRAGE images were acquired before (baseline) and after methemoglobin modulation. T1 of blood was measured with 2D ss EPl acquisitions with inversion recovery preparation performed at two-minute intervals up to 30 min. T1 maps were calculated by fitting the signal recovery curve within major blood vessels. Baseline T1 was 1758 ± 53 ms in carotid arteries and 1716 ± 41 ms in jugular veins. Sodium nitrite significantly changed intravascular T1 relaxation. The mean minimum value of T1 was 1126 ± 28 ms in carotid arteries 8 to 10 min after the injection of sodium nitrite. The mean minimum value of T1 was 1171 ± 52 ms in jugular veins 10 to 14 min after the injection of sodium nitrite. Arterial and venous T1 recovered to baseline after a period of 30 min. Methemoglobin modulation produces intravascular contrast on T1-weighted MRI in vivo. Additional studies are needed to safely optimize methemoglobin modulation and sequence parameters for maximal tissue contrast.
Identifiants
pubmed: 37392804
pii: S0730-725X(23)00114-5
doi: 10.1016/j.mri.2023.06.018
pmc: PMC10530177
mid: NIHMS1922632
pii:
doi:
Substances chimiques
Methemoglobin
9008-37-1
Contrast Media
0
Sodium Nitrite
M0KG633D4F
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NCATS NIH HHS
ID : UM1 TR004409
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.
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