Capillary electrokinetic chromatography for studying interactions between β-blockers and Intralipid emulsion.
Adsorption isotherm
Capillary electrokinetic chromatography
Distribution constant
Drug toxicities
Intralipid emulsion
β-blockers
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
20 Sep 2023
20 Sep 2023
Historique:
received:
15
05
2023
revised:
19
06
2023
accepted:
26
06
2023
medline:
28
8
2023
pubmed:
4
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
Toxicity of β-blockers is one of the most common causes of poison-induced cardiogenic shock throughout the world. Therefore, methodologies for in vivo removal of the drugs from the body have been under investigation. Intralipid emulsion (ILE) is a common commercial lipid emulsion used for parenteral nutrition, but it has also been administered to patients suffering from drug toxicities. In this work, a set of β-blockers of different hydrophobicity's (log K
Identifiants
pubmed: 37399701
pii: S0731-7085(23)00323-0
doi: 10.1016/j.jpba.2023.115554
pii:
doi:
Substances chimiques
soybean oil, phospholipid emulsion
0
Fat Emulsions, Intravenous
0
Phospholipids
0
Soybean Oil
8001-22-7
Adrenergic beta-Antagonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115554Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Susanne Wiedmer reports financial support was provided by the Finnish Society of Sciences and Letters. Torgny Fornstedt reports financial support was provided by Swedish Knowledge Foundation. Vaclav Kasicka reports financial support was provided by the Czech Academy of Sciences. Jorgen Samuelsson reports financial support was provided by Swedish Knowledge Foundation.