Elevated blood lactate in COPD exacerbations associates with adverse clinical outcomes and signals excessive treatment with β
COPD
biomarker
blood lactate
chronic obstructive pulmonary disease
exacerbations
non-invasive ventilation
salbutamol
β2-agonist
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
09
11
2022
accepted:
31
05
2023
medline:
21
8
2023
pubmed:
4
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
Raised blood lactate secondary to high dose β Retrospective (n = 199) and prospective studies (n = 142) of patients hospitalized with AECOPD were conducted. The retrospective cohort was identified via medical records and the prospective cohort was recruited during hospitalization for AECOPD. Baseline demographics, comorbidities, β Demographic data and comorbidities were similar between high versus normal lactate groups in both cohorts. The populations were elderly (mean >70 years), predominantly male (>60%) with reduced FEV Elevated lactate during AECOPD was common, unrelated to sepsis and correlated with high cumulative doses of β
Sections du résumé
BACKGROUND AND OBJECTIVE
Raised blood lactate secondary to high dose β
METHODS
Retrospective (n = 199) and prospective studies (n = 142) of patients hospitalized with AECOPD were conducted. The retrospective cohort was identified via medical records and the prospective cohort was recruited during hospitalization for AECOPD. Baseline demographics, comorbidities, β
RESULTS
Demographic data and comorbidities were similar between high versus normal lactate groups in both cohorts. The populations were elderly (mean >70 years), predominantly male (>60%) with reduced FEV
CONCLUSION
Elevated lactate during AECOPD was common, unrelated to sepsis and correlated with high cumulative doses of β
Substances chimiques
Adrenergic beta-2 Receptor Agonists
0
Lactates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
860-868Informations de copyright
© 2023 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.
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