Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions.

Intrinsically Disordered Proteins / chemistry Protein Conformation

Journal

Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604

Informations de publication

Date de publication:
09 2023
Historique:
received: 12 07 2022
accepted: 18 05 2023
medline: 8 9 2023
pubmed: 4 7 2023
entrez: 3 7 2023
Statut: ppublish

Résumé

An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

Identifiants

DOI: 10.1038/s41592-023-01915-x PMID: 37400558
pubmed: 37400558
doi: 10.1038/s41592-023-01915-x
pii: 10.1038/s41592-023-01915-x
doi:

Substances chimiques

Intrinsically Disordered Proteins 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1291-1303

Subventions

Organisme : Cancer Research UK
ID : 28159
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM109046
Pays : United States

Informations de copyright

© 2023. Springer Nature America, Inc.

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Auteurs

Bálint Mészáros (B)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Department of Structural Biology and Center for Data Driven Discovery, St Jude Children's Research Hospital, Memphis, TN, USA.
ORCID: 0000-0003-0919-4449

András Hatos (A)

Department of Biomedical Sciences, University of Padova, Padova, Italy.
Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Swiss Cancer Center Leman, Lausanne, Switzerland.
ORCID: 0000-0001-9224-9820

Nicolas Palopoli (N)

Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires, Argentina.

Federica Quaglia (F)

Department of Biomedical Sciences, University of Padova, Padova, Italy.
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy.

Edoardo Salladini (E)

Department of Biomedical Sciences, University of Padova, Padova, Italy.
ORCID: 0000-0002-5152-5953

Kim Van Roey (K)

Interuniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels, Belgium.
Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.

Haribabu Arthanari (H)

Harvard Medical School (HMS), Boston, MA, USA.
Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA.
ORCID: 0000-0002-7281-1289

Zsuzsanna Dosztányi (Z)

Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary.

Isabella C Felli (IC)

Department of Chemistry 'Ugo Schiff' and Magnetic Resonance Center, University of Florence, Sesto Fiorentino (Florence), Italy.

Patrick D Fischer (PD)

Harvard Medical School (HMS), Boston, MA, USA.
Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA.

Jeffrey C Hoch (JC)

Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA.

Cy M Jeffries (CM)

European Molecular Biology Laboratory (EMBL), Hamburg Unit, c/o Deutsches Elektronen-Synchrotron, Hamburg, Germany.
ORCID: 0000-0002-8718-7343

Sonia Longhi (S)

Laboratory Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), Marseille, France.
ORCID: 0000-0002-6829-6771

Emiliano Maiani (E)

Cancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
UniCamillus - Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
ORCID: 0000-0003-1432-5394

Sandra Orchard (S)

European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, UK.
ORCID: 0000-0002-8878-3972

Rita Pancsa (R)

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.

Elena Papaleo (E)

Cancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, Lyngby, Denmark.

Roberta Pierattelli (R)

Department of Chemistry 'Ugo Schiff' and Magnetic Resonance Center, University of Florence, Sesto Fiorentino (Florence), Italy.
ORCID: 0000-0001-7755-0885

Damiano Piovesan (D)

Department of Biomedical Sciences, University of Padova, Padova, Italy.

Iva Pritisanac (I)

Hospital for Sick Children, Toronto, Ontario, Canada.
Medical University of Graz, Graz, Austria.

Luiggi Tenorio (L)

Department of Biomedical Sciences, University of Padova, Padova, Italy.

Thibault Viennet (T)

Harvard Medical School (HMS), Boston, MA, USA.
Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA.
ORCID: 0000-0001-5349-0179

Peter Tompa (P)

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
VIB-VUB Center for Structural Biology, Brussels, Belgium.
Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0001-8042-9939

Wim Vranken (W)

Interuniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels, Belgium.
Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.
Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
ORCID: 0000-0001-7470-4324

Silvio C E Tosatto (SCE)

Department of Biomedical Sciences, University of Padova, Padova, Italy.
ORCID: 0000-0003-4525-7793

Norman E Davey (NE)

Division Of Cancer Biology, Institute of Cancer Research, Chester Beatty Laboratories, Chelsea, London, UK. norman.davey@icr.ac.uk.
ORCID: 0000-0001-6988-4850

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines intrinsèquement désordonnées › Minimum information guidelines for experiments...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Minimum information guidelines for experiments...