Sen1 and Rrm3 ensure permissive topological conditions for replication termination.

DNA DNA Helicases / genetics DNA Replication DNA Topoisomerases, Type II / metabolism RNA Helicases / genetics Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / genetics
CP: Molecular biology DNA topology RNPII Rrm3 Senataxin Top1 Top2 replication termination telomeres

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
25 07 2023
Historique:
received: 01 10 2022
revised: 17 04 2023
accepted: 20 06 2023
medline: 31 7 2023
pubmed: 5 7 2023
entrez: 5 7 2023
Statut: ppublish

Résumé

Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetics, genomics, and transmission electron microscopy, we find that Rrm3

Identifiants

DOI: 10.1016/j.celrep.2023.112747 PMID: 37405920
pubmed: 37405920
pii: S2211-1247(23)00758-1
doi: 10.1016/j.celrep.2023.112747
pii:
doi:

Substances chimiques

DNA 9007-49-2
DNA Helicases EC 3.6.4.-
DNA Topoisomerases, Type II EC 5.99.1.3
RNA Helicases EC 3.6.4.13
Saccharomyces cerevisiae Proteins 0
SEN1 protein, S cerevisiae EC 3.6.1.-
Rrm3 protein, S cerevisiae EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112747

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Ramveer Choudhary (R)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.

Joanna Niska-Blakie (J)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.

Mohamood Adhil (M)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.

Giordano Liberi (G)

Istituto di Genetica Molecolare "Luigi Luca Cavalli-Sforza," CNR, Pavia, Italy.

Yathish Jagadheesh Achar (YJ)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.

Michele Giannattasio (M)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milan, Italy.

Marco Foiani (M)

IFOM ETS - The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Festa del Perdono, 7, 20122 Milan, Italy. Electronic address: marco.foiani@ifom.eu.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Helicase › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › DNA topoisomerases › ADN topoisomérases de type II › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Sen1 and Rrm3 ensure permissive topological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Sen1 and Rrm3 ensure permissive topological...