Structural Transition of the Nucleosome during Transcription Elongation.
FACT
RNA polymerase II
chromatin
histone chaperone
nucleosome
template DNA looping
transcription
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
14 05 2023
14 05 2023
Historique:
received:
19
04
2023
revised:
10
05
2023
accepted:
11
05
2023
medline:
7
7
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
epublish
Résumé
In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during transcription elongation. After the RNA polymerase II passage, the nucleosome is rebuilt by transcription-coupled nucleosome reassembly. Nucleosome disassembly-reassembly processes play a central role in preserving epigenetic information, thus ensuring transcriptional fidelity. The histone chaperone FACT performs key functions in nucleosome disassembly, maintenance, and reassembly during transcription in chromatin. Recent structural studies of transcribing RNA polymerase II complexed with nucleosomes have provided structural insights into transcription elongation on chromatin. Here, we review the structural transitions of the nucleosome during transcription.
Identifiants
pubmed: 37408222
pii: cells12101388
doi: 10.3390/cells12101388
pmc: PMC10216454
pii:
doi:
Substances chimiques
Nucleosomes
0
RNA Polymerase II
EC 2.7.7.-
Chromatin
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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