Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.

Cryoelectron Microscopy Protozoan Proteins / genetics RNA Editing RNA, Guide, Kinetoplastida / chemistry RNA, Messenger / chemistry Trypanosoma brucei brucei / genetics RNA Stability RNA, Protozoan / chemistry

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
07 07 2023
Historique:
medline: 10 7 2023
pubmed: 6 7 2023
entrez: 6 7 2023
Statut: ppublish

Résumé

In

Identifiants

DOI: 10.1126/science.adg4725 PMID: 37410820 PMC: PMC10704856
pubmed: 37410820
doi: 10.1126/science.adg4725
pmc: PMC10704856
mid: NIHMS1941102
doi:

Substances chimiques

Protozoan Proteins 0
RNA, Guide, Kinetoplastida 0
RNA, Messenger 0
RNA, Protozoan 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg4725

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM145249
Pays : United States
Organisme : NIH HHS
ID : S10 OD018111
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023057
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM074830
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152408
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113157
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101057
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM116792
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM071940
Pays : United States

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Auteurs

Shiheng Liu (S)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0002-0561-1981

Hong Wang (H)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.
ORCID: 0000-0002-5767-2882

Xiaorun Li (X)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0003-2100-7554

Fan Zhang (F)

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
ORCID: 0000-0002-2858-0698

Jane K J Lee (JKJ)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0001-7735-7647

Zihang Li (Z)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0002-4625-9283

Clinton Yu (C)

Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
ORCID: 0000-0002-2931-5474

Jason J Hu (JJ)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0002-1103-2177

Xiaojing Zhao (X)

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Takuma Suematsu (T)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.
ORCID: 0000-0003-1430-6580

Ana L Alvarez-Cabrera (AL)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0001-7186-9393

Qiushi Liu (Q)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.

Liye Zhang (L)

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Shanghai Clinical Research and Trial Center, Shanghai 201210, China.
ORCID: 0000-0003-2104-6828

Lan Huang (L)

Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
ORCID: 0000-0002-3140-4687

Inna Aphasizheva (I)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.
ORCID: 0000-0003-2695-2950

Ruslan Aphasizhev (R)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.
Department of Biochemistry, Boston University Medical Campus, Boston, MA, USA.
ORCID: 0000-0002-4595-6618

Z Hong Zhou (ZH)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
California NanoSystems Institute, University of California, Los Angeles, CA, USA.
ORCID: 0000-0002-8373-4717

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Édition des ARN › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › ARN guide › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité de l'ARN › Structural basis of gRNA stabilization and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN des protozoaires › Structural basis of gRNA stabilization and...