Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues.
Frizzled
Liver
Organoids
R-spondin
SWAP
Salivary gland
Surrozen Wnt activating proteins
WNT
WNT Superagonist
WNT mimetic
Journal
Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030
Informations de publication
Date de publication:
17 08 2023
17 08 2023
Historique:
received:
14
12
2022
revised:
18
04
2023
accepted:
06
06
2023
medline:
21
8
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
WNTs are essential factors for stem cell biology, embryonic development, and for maintaining homeostasis and tissue repair in adults. Difficulties in purifying WNTs and their lack of receptor selectivity have hampered research and regenerative medicine development. While breakthroughs in WNT mimetic development have overcome some of these difficulties, the tools developed so far are incomplete and mimetics alone are often not sufficient. Here, we developed a complete set of WNT mimetic molecules that cover all WNT/β-catenin-activating Frizzleds (FZDs). We show that FZD
Identifiants
pubmed: 37413985
pii: S2451-9456(23)00183-6
doi: 10.1016/j.chembiol.2023.06.006
pii:
doi:
Substances chimiques
beta Catenin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
976-986.e5Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests All authors are current or former full-time employees and shareholders of Surrozen, Inc. W.C.Y. is Chief Scientific Officer and Y.L. is Senior Vice President, Biology at Surrozen, Inc. A patent application is pending for the work described in this manuscript.