Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A.
Journal
Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
medline:
21
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
epublish
Résumé
Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC
Identifiants
pubmed: 37417819
doi: 10.1039/d3ob00836c
pmc: PMC10529636
mid: NIHMS1913070
doi:
Substances chimiques
Nucleosides
0
Thymine
QR26YLT7LT
Exodeoxyribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5873-5879Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM136023
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM131627
Pays : United States
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