Decreased thalamocortical connectivity in resolved Rolandic epilepsy.
BECTS
CECTS
Idiopathic focal epilepsy
SeLECTS
Self-limited epilepsy with centrotemporal spikes
Thalamus
Journal
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
28
03
2023
revised:
09
05
2023
accepted:
24
05
2023
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
8
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Median nerve somatosensory evoked fields (SEFs) conduction times reflect the integrity of neural transmission across the thalamocortical circuit. We hypothesized median nerve SEF conduction time would be abnormal in children with Rolandic epilepsy (RE). 22 children with RE (10 active; 12 resolved) and 13 age-matched controls underwent structural and diffusion MRI and median nerve and visual stimulation during magnetoencephalography (MEG). N20 SEF responses were identified in contralateral somatosensory cortices. P100 were identified in contralateral occipital cortices as controls. Conduction times were compared between groups in linear models controlling for height. N20 conduction time was also compared to thalamic volume and Rolandic thalamocortical structural connectivity inferred using probabilistic tractography. The RE group had slower N20 conduction compared to controls (p = 0.042, effect size 0.6 ms) and this difference was driven by the resolved RE group (p = 0.046). There was no difference in P100 conduction time between groups (p = 0.83). Ventral thalamic volume positively correlated with N20 conduction time (p = 0.014). Children with resolved RE have focally decreased Rolandic thalamocortical connectivity. These results identify a persistent focal thalamocortical circuit abnormality in resolved RE and suggest that decreased Rolandic thalamocortical connectivity may support symptom resolution in this self-limited epilepsy.
Identifiants
pubmed: 37419052
pii: S1388-2457(23)00644-2
doi: 10.1016/j.clinph.2023.05.013
pmc: PMC10520846
mid: NIHMS1911882
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-27Subventions
Organisme : NINDS NIH HHS
ID : K23 NS092923
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115868
Pays : United States
Informations de copyright
Copyright © 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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