Enantioseparation of two antifungal azole drugs by analytical countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector.
Countercurrent chromatography
Enantioseparation
Molecular docking
Sulfobutyl ether-β-cyclodextrin
Voriconazole
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
30 Aug 2023
30 Aug 2023
Historique:
received:
10
05
2023
revised:
24
06
2023
accepted:
27
06
2023
medline:
9
8
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
This study reports a successful enantioseparation of two antifungal drugs, Ketoconazole and Voriconazole, using countercurrent chromatography (CCC) with synthesized sulfobutyl ether-β-cyclodextrin (SBE-β-CD) as chiral selector. Two biphasic solvent systems composed of dichloromethane: 0.1 mol L
Identifiants
pubmed: 37429079
pii: S0021-9673(23)00411-9
doi: 10.1016/j.chroma.2023.464185
pii:
doi:
Substances chimiques
SBE4-beta-cyclodextrin
2PP9364507
Antifungal Agents
0
Azoles
0
Voriconazole
JFU09I87TR
beta-Cyclodextrins
0
Phosphates
0
Ethers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
464185Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.