Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1.

Humans T-Lymphocytes, Regulatory Immunity, Innate CD4-Positive T-Lymphocytes Leukocyte-Adhesion Deficiency Syndrome Th17 Cells
ILC LAD-1 Leukocyte adhesion deficiency Th17 Treg

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
08 2023
Historique:
received: 13 03 2023
revised: 26 05 2023
accepted: 05 07 2023
medline: 26 7 2023
pubmed: 12 7 2023
entrez: 11 7 2023
Statut: ppublish

Résumé

In 15 Turkish LAD-1 patients and controls, we assessed the impact of pathogenic ITGB2 mutations on Th17/Treg differentiation and functions, and innate lymphoid cell (ILC) subsets. The percentage of peripheral blood Treg cells, in vitro-generated induced Tregs differentiated from naive CD4

Identifiants

DOI: 10.1016/j.clim.2023.109691 PMID: 37433423
pubmed: 37433423
pii: S1521-6616(23)00454-0
doi: 10.1016/j.clim.2023.109691
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109691

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing interest.

Auteurs

Serife Erdem (S)

Erciyes University School of Medicine, Department of Medical Biology, Kayseri, Turkey; Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey.

Sule Haskologlu (S)

Ankara University School of Medicine, Department of Pediatric Allergy and Immunology, Ankara, Turkey.

Yesim Haliloglu (Y)

Erciyes University School of Medicine, Department of Medical Biology, Kayseri, Turkey; Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey.

Huriye Celikzencir (H)

Erciyes University School of Medicine, Department of Immunology, Kayseri, Turkey.

Elif Arik (E)

Gaziantep University School of Medicine, Department of Pediatric Allergy and Immunology, Gaziantep, Turkey.

Ozlem Keskin (O)

Gaziantep University School of Medicine, Department of Pediatric Allergy and Immunology, Gaziantep, Turkey.

Sevgi Bilgic Eltan (SB)

Marmara University School of Medicine, Department of Pediatric Allergy and Immunology, Istanbul, Turkey.

Esra Yucel (E)

Istanbul University School of Medicine, Department of Pediatric Allergy and Immunology, Istanbul, Turkey.

Halit Canatan (H)

Erciyes University School of Medicine, Department of Medical Biology, Kayseri, Turkey; Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey.

Huseyin Avcilar (H)

Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey.

Ebru Yilmaz (E)

Erciyes University School of Medicine, Department of Pediatric Hematology and Oncology, Kayseri, Turkey.

Alper Ozcan (A)

Erciyes University School of Medicine, Department of Pediatric Hematology and Oncology, Kayseri, Turkey.

Ekrem Unal (E)

Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey; Erciyes University School of Medicine, Department of Pediatric Hematology and Oncology, Kayseri, Turkey.

Musa Karakukcu (M)

Erciyes University School of Medicine, Department of Pediatric Hematology and Oncology, Kayseri, Turkey.

Mehmet Halil Celiksoy (MH)

İstanbul Başakşehir Çam ve Sakura City Hospital, University of Health Sciences, Pediatric Allergy and Immunology Clinic, Istanbul, Turkey.

Sara Sebnem Kilic (SS)

Bursa Uludag University, School of Medicine, Department of Pediatric Immunology and Rheumatology, Bursa, Turkey.

Ayca Demir (A)

Dr Behcet Uz Children's Education and Research Hospital, University of Health Sciences, Department of Pediatric Allergy and Immunology, Izmir, Turkey.

Ferah Genel (F)

Dr Behcet Uz Children's Education and Research Hospital, University of Health Sciences, Department of Pediatric Allergy and Immunology, Izmir, Turkey.

Nesrin Gulez (N)

Dr Behcet Uz Children's Education and Research Hospital, University of Health Sciences, Department of Pediatric Allergy and Immunology, Izmir, Turkey.

Mustafa Yavuz Koker (MY)

Erciyes University School of Medicine, Department of Immunology, Kayseri, Turkey.

Ahmet Oguzhan Ozen (AO)

Marmara University School of Medicine, Department of Pediatric Allergy and Immunology, Istanbul, Turkey.

Safa Baris (S)

Marmara University School of Medicine, Department of Pediatric Allergy and Immunology, Istanbul, Turkey.

Ayse Metin (A)

Ankara City Hospital, University of Health Sciences, Department of Pediatric Allergy and Immunology, Ankara, Turkey.

Sukru Nail Guner (SN)

Necmettin Erbakan University School of Medicine, Department of Pediatric Allergy and Immunology, Konya, Turkey.

Ismail Reisli (I)

Necmettin Erbakan University School of Medicine, Department of Pediatric Allergy and Immunology, Konya, Turkey.

Sevgi Keles (S)

Necmettin Erbakan University School of Medicine, Department of Pediatric Allergy and Immunology, Konya, Turkey.

Esin Figen Dogu (EF)

Ankara University School of Medicine, Department of Pediatric Allergy and Immunology, Ankara, Turkey.

Kamile Aydan Ikinciogullari (KA)

Ankara University School of Medicine, Department of Pediatric Allergy and Immunology, Ankara, Turkey.

Ahmet Eken (A)

Erciyes University School of Medicine, Department of Medical Biology, Kayseri, Turkey; Erciyes University, Betul-Ziya Eren Genome and Stem Cell Center, Kayseri, Turkey. Electronic address: ahmet.eken@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Defective Treg generation and increased type 3...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Defective Treg generation and increased type 3...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Defective Treg generation and increased type 3...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Defective Treg generation and increased type 3...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Maladies d'immunodéficience primaire › Déficit d'adhérence leucocytaire › Defective Treg generation and increased type 3...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Defective Treg generation and increased type 3...