Recruited macrophages elicit atrial fibrillation.

Animals Humans Mice Atrial Fibrillation / genetics Heart Atria Macrophages / immunology Mitral Valve Insufficiency / genetics Osteopontin / genetics Gene Deletion Cell Movement Single-Cell Gene Expression Analysis

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
14 07 2023
Historique:
medline: 17 7 2023
pubmed: 13 7 2023
entrez: 13 7 2023
Statut: ppublish

Résumé

Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria documented inflammatory monocyte and

Identifiants

DOI: 10.1126/science.abq3061 PMID: 37440641 PMC: PMC10448807
pubmed: 37440641
doi: 10.1126/science.abq3061
pmc: PMC10448807
mid: NIHMS1919677
doi:

Substances chimiques

Spp1 protein, mouse 0
Osteopontin 106441-73-0
SPP1 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

231-239

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL149647
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA225655
Pays : United States
Organisme : British Heart Foundation
ID : PG/2019/34842
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/12/3/29609
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL157635
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL158040
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007604
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092577
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : British Heart Foundation
ID : RG/16/12/32451
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : P01 HL142494
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139598
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155097
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Maarten Hulsmans (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-1009-658X

Maximilian J Schloss (MJ)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0009-0007-4979-690X

I-Hsiu Lee (IH)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7200-7867

Aneesh Bapat (A)

Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1996-522X

Yoshiko Iwamoto (Y)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Claudio Vinegoni (C)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9818-3639

Alexandre Paccalet (A)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6331-562X

Masahiro Yamazoe (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Jana Grune (J)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-6209-7416

Steffen Pabel (S)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

Noor Momin (N)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3145-6089

Hana Seung (H)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0009-0004-7754-787X

Nina Kumowski (N)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3355-9102

Fadi E Pulous (FE)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-0794-8078

Daniel Keller (D)

Department of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
ORCID: 0009-0005-5776-3310

Constanze Bening (C)

Department of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.

Ursula Green (U)

Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-5842-280X

Jochen K Lennerz (JK)

Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-2434-4978

Richard N Mitchell (RN)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-0329-7618

Andrew Lewis (A)

Radcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.
ORCID: 0000-0002-3714-6711

Barbara Casadei (B)

Radcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.
ORCID: 0000-0002-6801-1617

Oriol Iborra-Egea (O)

Institut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain.
ORCID: 0000-0002-7280-859X

Antoni Bayes-Genis (A)

Institut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain.
ORCID: 0000-0002-3044-197X

Samuel Sossalla (S)

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Department of Cardiology and Angiology, University of Giessen/DZHK, Partner Site Rhein-Main, Germany.

Chin Siang Ong (CS)

Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-4521-0971

Richard N Pierson (RN)

Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3764-4590

Jon C Aster (JC)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

David Rohde (D)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3785-9375

Gregory R Wojtkiewicz (GR)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3148-8411

Ralph Weissleder (R)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-0828-4143

Filip K Swirski (FK)

Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-3163-9152

George Tellides (G)

Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
ORCID: 0000-0001-7042-8190

George Tolis (G)

Department of Cardiac Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Serguei Melnitchouk (S)

Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0009-0009-2983-3472

David J Milan (DJ)

Leducq Foundation, Boston, MA, USA.

Patrick T Ellinor (PT)

Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
ORCID: 0000-0002-2067-0533

Kamila Naxerova (K)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7744-5110

Matthias Nahrendorf (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany.
ORCID: 0000-0002-4021-1887

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Système cardiovasculaire › Coeur › Atrium du coeur › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › Insuffisance mitrale › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Ostéopontine › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Recruited macrophages elicit atrial fibrillation.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Analyse de l'expression du gène de la cellule unique › Recruited macrophages elicit atrial fibrillation.