Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1.
cerebellum
edaravone
mitochondria
neurodegeneration
spinocerebellar ataxia type 1
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Jun 2023
26 Jun 2023
Historique:
received:
31
05
2023
revised:
19
06
2023
accepted:
21
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 (SCA1), an incurable neurodegenerative disease characterized mainly by cerebellar disorder, with a strong contribution of inflammation and mitochondrial dysfunction. This study aimed to address this gap, exploring the potential of edaravone to slow down SCA1 progression in a mouse knock-in SCA1 model. SCA1
Identifiants
pubmed: 37445867
pii: ijms241310689
doi: 10.3390/ijms241310689
pmc: PMC10341848
pii:
doi:
Substances chimiques
Edaravone
S798V6YJRP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Charles University
ID : GAUK24120
Organisme : Charles University
ID : Cooperatio, areas NEUR, IMMU, DIAG
Organisme : Ministry of Education Youth and Sports
ID : CZ.02.1.01/0.0/0.0/16_019/0000787
Organisme : Ministry of Education Youth and Sports
ID : LX22NPO5107
Organisme : Charles University
ID : Specific Student Research Project 260653/2023
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The study has been financed by research grants. The authors are employed by academic institutions.
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