Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae.
Animals
Zebrafish
/ genetics
Trichlorfon
/ metabolism
Organophosphorus Compounds
/ toxicity
Acetylcholinesterase
/ genetics
Larva
/ metabolism
Acetylcholine
/ metabolism
Dopamine
/ metabolism
Molecular Docking Simulation
Serotonin
/ metabolism
Pesticides
/ metabolism
Embryo, Nonmammalian
/ metabolism
Water Pollutants, Chemical
/ toxicity
central nervous system
developmental neurotoxicity
neurotransmitter system
trichlorfon
zebrafish embryos/larvae
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Jul 2023
04 Jul 2023
Historique:
received:
16
06
2023
revised:
27
06
2023
accepted:
03
07
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Trichlorfon is an organophosphorus pesticide widely used in aquaculture and has potential neurotoxicity, but the underlying mechanism remains unclear. In the present study, zebrafish embryos were exposed to trichlorfon at concentrations (0, 0.1, 2 and 5 mg/L) used in aquaculture from 2 to 144 h post fertilization. Trichlorfon exposure reduced the survival rate, hatching rate, heartbeat and body length and increased the malformation rate of zebrafish larvae. The locomotor activity of larvae was significantly reduced. The results of molecular docking revealed that trichlorfon could bind to acetylcholinesterase (AChE). Furthermore, trichlorfon significantly inhibited AChE activity, accompanied by decreased acetylcholine, dopamine and serotonin content in larvae. The transcription patterns of genes related to acetylcholine (e.g.,
Identifiants
pubmed: 37446277
pii: ijms241311099
doi: 10.3390/ijms241311099
pmc: PMC10342510
pii:
doi:
Substances chimiques
Trichlorfon
DBF2DG4G2K
Organophosphorus Compounds
0
Acetylcholinesterase
EC 3.1.1.7
Acetylcholine
N9YNS0M02X
Dopamine
VTD58H1Z2X
Serotonin
333DO1RDJY
Pesticides
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 22106040
Organisme : the Scientific and Technological Project of Henan Province
ID : 232102320079
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