Medicines postpartum in Sweden and coverage in Janusmed Breastfeeding.

Breast feeding milk Clinical database management systems Human cohort studies decision support systems Janusmed breastfeeding  Medicines Postpartum

Journal

European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 12 10 2022
accepted: 15 06 2023
medline: 17 8 2023
pubmed: 15 7 2023
entrez: 15 7 2023
Statut: ppublish

Résumé

The purpose of this article is (1) to investigate which medicines are prescribed and dispensed to women the first 6 months postpartum, (2) to identify medicines dispensed postpartum but not recommended during breastfeeding, and (3) to find medicines commonly dispensed postpartum, but not currently included in Janusmed Breastfeeding. In this register-based cohort study covering births between January 2017 and August 2019, the Swedish Medical Birth Register (MBR), the Prescribed Drug Register, and Janusmed Breastfeeding were linked to identify medicines dispensed to women during the first 6 months postpartum, and how they are covered and classified in Janusmed Breastfeeding. During the first 6 months postpartum, 66% of women purchased at least one prescription medicine from the pharmacy. The most common medicines were contraceptive agents, analgesics, antibiotics, and glucocorticoids. A third of the 30 most commonly dispensed medicines have no information available about the safety of use in breastfeeding. The most dispensed medicines, where the database advises against use in breastfeeding, included several antitussive agents, a local anaesthetic, and several gestagens. The most commonly dispensed medicines not covered by the Janusmed Breastfeeding were medicines for dry eyes, for assisted reproduction, and HIV. Prescribed medicines compatible with breastfeeding are more common during the first 6 months postpartum than medicines not compatible with breastfeeding, but medicines which lack evidence for safety in breastfeeding are still commonly used.

Identifiants

pubmed: 37452835
doi: 10.1007/s00228-023-03528-x
pii: 10.1007/s00228-023-03528-x
pmc: PMC10427528
doi:

Substances chimiques

Progestins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1261-1269

Informations de copyright

© 2023. The Author(s).

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Auteurs

A B Asplund (AB)

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. annika.asplund@ki.se.

P Dreher Sköld (PD)

Department of Knowledge Development, Health and Medical Care Administration, Region Stockholm, Sweden.

L Karlsson Lind (LK)

Department of Knowledge Development, Health and Medical Care Administration, Region Stockholm, Sweden.

C E Cesta (CE)

Department of Medicine Solna, Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.

M L Dahl (ML)

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

E Wikström Jonsson (EW)

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

M L Andersson (ML)

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Classifications MeSH