Structure-switching aptasensors for sensitive detection of ochratoxin A.
G-triplex
aptasensor
fluorescence
ochratoxin A
structure-switching aptamer
Journal
Luminescence : the journal of biological and chemical luminescence
ISSN: 1522-7243
Titre abrégé: Luminescence
Pays: England
ID NLM: 100889025
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
27
06
2023
received:
07
05
2023
accepted:
11
07
2023
medline:
5
9
2023
pubmed:
17
7
2023
entrez:
16
7
2023
Statut:
ppublish
Résumé
Ochratoxin A (OTA) is a toxic metabolite commonly found in various foods and feedstuffs. Accurate and sensitive detection of OTA is needed for food safety and human health. Based on a common OTA-binding aptamer (OTABA), two structure-switching OTABAs, namely OTABA4 and OTABA3, were designed by configuring a split G-quadruplex and a split G-triplex, respectively, at the two ends of OTABA to construct aptasensors for the detection of OTA. The OTABA, G-quadruplex, and G-triplex all can capture the thioflavin T (ThT) probe, thereby enhancing the fluorescence intensity of ThT. Bonding with OTA could change the conformations of OTABA and G-quadruplex or G-triplex regions, resulting in the release of the captured ThT and diminution of its fluorescence intensity. Dual conformation changes in structure-switching OTABA synergistically amplified the fluorescence signal and improved the sensitivity of the aptasensor, especially for that with OTABA3. The detection limits of the OTABA4-ThT and OTABA3-ThT systems for OTA were 0.28 and 0.059 ng ml
Substances chimiques
ochratoxin A
1779SX6LUY
Aptamers, Nucleotide
0
Ochratoxins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1678-1685Subventions
Organisme : National Natural Science Foundation of China
ID : 22274092
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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