Genome-wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in carriers of the HLA-A*03:01 allele.
BNT162b2
GWAS
HLA-A*03:01
SARS-CoV-2
SARS-CoV-2 spike antibodies
side effects
vaccine
Journal
HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
25
05
2023
received:
20
03
2023
accepted:
06
07
2023
medline:
13
11
2023
pubmed:
20
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
The remarkable variability of response to vaccines against SARS-CoV-2 is apparent. The present study aims to estimate the extent to which the host genetic background contributes to this variability in terms of immune response and side effects following the administration of the BNT162b2 vaccine. We carried out a genome wide association study (GWAS) by genotyping 873 Italian healthcare workers who underwent anti-SARS-CoV-2 vaccination with the BNT162b2 vaccine and for whom information about anti-SARS-CoV-2 spike antibodies titers and vaccine side effects were available. The GWAS revealed a significant association between the HLA locus and the anti-SARS-CoV-2 Spike antibodies level at 2 months following the first dose of vaccine (SNP: rs1737060; p = 9.80 × 10
Substances chimiques
BNT162 Vaccine
0
COVID-19 Vaccines
0
Vaccines
0
Antibodies, Viral
0
HLA-A Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-719Informations de copyright
© 2023 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons Ltd.
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