α-Glucosidase inhibition by green, white and oolong teas:
catechins
molecular docking
polyphenols
tea
α-glucosidase inhibition
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
21
7
2023
pubmed:
20
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
Natural α-glucosidase inhibitors from plant-based foods such as catechins offer an attractive strategy for their potential anti-diabetic effects. In this study, infusions of three different tea types (green, white, and oolong) were investigated for their total phenolic (TPC) and catechins (EGCG, ECG, EGC, and EC) content, and for their α-glucosidase inhibitory activities. We observed that the level of TPC in white tea was significantly higher compared to oolong and green tea, which suggests higher content of EGCG and ECG catechins in fresh young leaves. Our findings showed that the higher content of such catechins in the infusion of white tea well correlated with a strong inhibition of α-glucosidase, and such inhibition was demonstrated to be more effective than the FDA-approved drug acarbose. Then, we computationally explored the molecular requirements for enzyme inhibition, especially for the most active catechins EGCG and ECG, as well as their disposition/stability within the active site.
Identifiants
pubmed: 37470394
doi: 10.1080/14756366.2023.2236802
pmc: PMC10361001
doi:
Substances chimiques
alpha-Glucosidases
EC 3.2.1.20
Catechin
8R1V1STN48
Phenols
0
Plant Extracts
0
Tea
0
Glycoside Hydrolase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2236802Références
Front Nutr. 2022 Dec 05;9:1060783
pubmed: 36545470
J Agric Food Chem. 2015 Feb 25;63(7):2026-32
pubmed: 25599125
J Agric Food Chem. 2012 Sep 12;60(36):8924-9
pubmed: 22697360
J Chem Inf Model. 2021 Aug 23;61(8):3891-3898
pubmed: 34278794
Curr Top Med Chem. 2010;10(4):434-57
pubmed: 20180758
J Comput Chem. 2009 Dec;30(16):2785-91
pubmed: 19399780
Antioxidants (Basel). 2019 Jun 10;8(6):
pubmed: 31185622
Talanta. 2002 May 16;57(2):307-16
pubmed: 18968631
ScientificWorldJournal. 2013 Aug 07;2013:368350
pubmed: 23997676
J Agric Food Chem. 2014 May 21;62(20):4610-7
pubmed: 24785184
Curr Diabetes Rev. 2010 Jul;6(4):247-54
pubmed: 20522017
Nutr Metab Cardiovasc Dis. 2002 Apr;12(2):98-107
pubmed: 12189909
BMC Pharmacol. 2004 Aug 26;4:18
pubmed: 15331020
Food Chem. 2013 Dec 1;141(3):2379-84
pubmed: 23870971
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Plants (Basel). 2022 Oct 14;11(20):
pubmed: 36297746
J Comput Chem. 2010 Mar;31(4):671-90
pubmed: 19575467
Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:594-602
pubmed: 27524059
Chem Cent J. 2008 Mar 09;2:5
pubmed: 18328109
Nat Struct Mol Biol. 2004 Apr;11(4):380-1
pubmed: 15024383
Int J Biol Macromol. 2020 Jan 15;143:696-703
pubmed: 31521662
Nat Protoc. 2007;2(4):875-7
pubmed: 17446889
Foods. 2021 Aug 20;10(8):
pubmed: 34441720
Food Chem. 2021 Nov 1;361:130047
pubmed: 34029903
Int J Pharm. 2011 Apr 15;408(1-2):97-101
pubmed: 21310224
J Food Sci. 2009 Mar;74(2):H47-51
pubmed: 19323750
Nutrients. 2018 Dec 06;10(12):
pubmed: 30563268
Cancer Res. 2008 Jun 1;68(11):4150-62
pubmed: 18519674
Mini Rev Med Chem. 2010 Apr;10(4):315-31
pubmed: 20470247
Food Funct. 2019 Jul 17;10(7):4407-4413
pubmed: 31282911
J Agric Food Chem. 2010 Jan 13;58(1):148-54
pubmed: 20050703
Am J Clin Nutr. 2013 Dec;98(6 Suppl):1642S-1650S
pubmed: 24172299
J Biomed Res. 2017 Nov 01;:
pubmed: 29089472
Food Chem. 2008 Oct 15;110(4):852-8
pubmed: 26047270
Protein Cell. 2011 Oct;2(10):827-36
pubmed: 22058037