PerIoperative iNflammatory reSponse assessment In hiGH-risk patienTs undergoing non-cardiac surgery (INSIGHT): study protocol of a prospective non-interventional observational study.
Adult anaesthesia
Ischaemic heart disease
SURGERY
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
medline:
24
7
2023
pubmed:
21
7
2023
entrez:
20
7
2023
Statut:
epublish
Résumé
Increased inflammatory processes after non-cardiac surgery are very common. The association between postoperative inflammation and the occurrence of cardiovascular complications after non-cardiac surgery are still not entirely clear. Therefore, we will evaluate the association between postoperative inflammation and the occurrence of major cardiovascular complications in patients at-risk for cardiovascular complications undergoing non-cardiac surgery. We will further evaluate the association of postoperative inflammation and days-at-home within 30 days after surgery (DAH In this multicentre study, we will include 1400 patients at-risk for cardiovascular complications undergoing non-cardiac surgery. Our primary aim is to evaluate the association of postoperative maximum C-reactive protein concentration and the occurrence of a composite of five major cardiovascular complications (myocardial infarction, myocardial injury after non-cardiac surgery, new onset of atrial fibrillation, stroke and death) within 30 days after surgery using a Mann-Whitney-U test as well as a logistic regression model. As our secondary aim, we will evaluate the association of a composite of three inflammatory biomarkers (interleukin 6, procalcitonin and copeptin) on the occurrence of our composite of five cardiovascular complications within 30 days and 1 year after surgery, acute kidney injury, DAH This study was approved by the ethics committees at the Medical University of Vienna (2458/2020) and at the Medical University of Graz (33-274 ex 20/21). NCT04753307.
Identifiants
pubmed: 37474184
pii: bmjopen-2022-065469
doi: 10.1136/bmjopen-2022-065469
pmc: PMC10357807
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
Natriuretic Peptide, Brain
114471-18-0
Banques de données
ClinicalTrials.gov
['NCT04753307']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e065469Investigateurs
Alexander Pichler
(A)
Christian Reiterer
(C)
Michael Eichlseder
(M)
Alexandra Graf
(A)
Michael Eichinger
(M)
Barbara Kabon
(B)
Nicole Hantakova
(N)
Simon Schallmeiner
(S)
Melanie Kuhrn
(M)
Andrea Kurz
(A)
Alexander Taschner
(A)
Daniel Freidorfer
(D)
David West
(D)
Andreas Heri
(A)
Stefan Trinkl
(S)
Tobias Marr
(T)
Melanie Fraunschiel
(M)
Victor Xu
(V)
Andreas Bayer
(A)
Asmir Osmanovic
(A)
Tobias Niedrist
(T)
Edith Fleischmann
(E)
Nikolas Adamowitsch
(N)
Katharina Horvath
(K)
Moritz Morgenroth
(M)
Georg Vitousek
(G)
Hani Essber
(H)
Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Heart. 2010 Jan;96(1):56-62
pubmed: 19861299
Anesthesiology. 2020 May;132(5):1053-1061
pubmed: 31929326
BMJ Open. 2017 Aug 18;7(8):e015828
pubmed: 28821518
JAMA Cardiol. 2017 Feb 1;2(2):181-187
pubmed: 28030663
Trials. 2020 May 12;21(1):400
pubmed: 32398119
Anesthesiology. 2013 Aug;119(2):270-83
pubmed: 23528538
BMC Anesthesiol. 2020 Aug 21;20(1):210
pubmed: 32825817
Ann Intern Med. 2020 Jan 21;172(2):96-104
pubmed: 31869834
Br J Gen Pract. 2002 May;52(478):373-4, 377-80
pubmed: 12014534
Lancet. 2018 Jan 27;391(10118):319-328
pubmed: 29146124
Eur Heart J. 2014 Jul 14;35(27):1782-91
pubmed: 24864079
Physiol Res. 2000;49 Suppl 1:S57-61
pubmed: 10984072
Rev Endocr Metab Disord. 2019 Sep;20(3):283-294
pubmed: 31656992
Anesthesiology. 2012 Mar;116(3):658-64
pubmed: 22277949
Br J Surg. 2017 Jun;104(7):868-876
pubmed: 28218392
Neuro Endocrinol Lett. 2008 Jun;29(3):341-6
pubmed: 18580851
BMC Anesthesiol. 2020 Aug 4;20(1):192
pubmed: 32753064
Curr Med Res Opin. 2018 Oct;34(10):1829-1837
pubmed: 29613817
Br J Anaesth. 2020 Nov;125(5):661-671
pubmed: 32718726
Br J Surg. 2006 Sep;93(9):1069-76
pubmed: 16888706
Surgery. 2021 Oct;170(4):1131-1139
pubmed: 34024474
J Fam Pract. 2006 Feb;55(2):130-4
pubmed: 16451780
Am Heart J. 2012 Dec;164(6):918-24
pubmed: 23194493
Lancet. 2010 Jan 9;375(9709):132-40
pubmed: 20031199
Anesthesiology. 2015 Dec;123(6):1301-11
pubmed: 26492475
Ann Intensive Care. 2016 Dec;6(1):116
pubmed: 27878573
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Br J Anaesth. 2019 Feb;122(2):180-187
pubmed: 30686303
Clin Biochem Rev. 2017 Apr;38(2):59-68
pubmed: 29332972
Ann Surg. 2016 Jun;263(6):1207-12
pubmed: 26135695
N Engl J Med. 2005 Apr 21;352(16):1685-95
pubmed: 15843671
Rev Esp Cardiol (Engl Ed). 2014 Oct;67(10):794-6
pubmed: 25205649
Heart. 2018 Jul;104(14):1180-1186
pubmed: 29305561
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
BMJ. 2018 Apr 23;361:k1036
pubmed: 29685876
Best Pract Res Clin Anaesthesiol. 2004 Sep;18(3):493-507
pubmed: 15212341
J Clin Anesth. 2021 Oct;73:110379
pubmed: 34087659
JAMA. 2017 Apr 25;317(16):1642-1651
pubmed: 28444280
Lancet. 2019 Sep 21;394(10203):1022-1029
pubmed: 31422895
Lancet. 2008 May 31;371(9627):1839-47
pubmed: 18479744
Surgeon. 2011 Feb;9(1):38-43
pubmed: 21195330
J Gastrointest Surg. 2016 Aug;20(8):1482-92
pubmed: 27206502
JAMA. 2012 Jun 6;307(21):2295-304
pubmed: 22706835
CMAJ. 2005 Sep 13;173(6):627-34
pubmed: 16157727
Anesth Analg. 2016 Dec;123(6):1363-1371
pubmed: 27870734
Circ J. 2011;75(5):1184-91
pubmed: 21378450
Clin Exp Med. 2020 Nov;20(4):481-491
pubmed: 32785793
Eur Heart J. 2014 Mar;35(9):578-89
pubmed: 24026779