Hair-based rapid UPLC-MS/MS analysis of 36 phencyclidine-type substances in forensic cases.

Phencyclidine Chromatography, High Pressure Liquid Chromatography, Liquid Tandem Mass Spectrometry Hair Acetonitriles
Authentic forensic cases Human hair New psychoactive substances (NPSs) Phencyclidine-type substances UPLC-MS/MS

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
20 Sep 2023
Historique:
received: 02 05 2023
revised: 06 07 2023
accepted: 11 07 2023
medline: 28 8 2023
pubmed: 23 7 2023
entrez: 22 7 2023
Statut: ppublish

Résumé

Phencyclidine (PCP) is a frequently abused dissociative agent. It causes confusion, increased tendencies toward violence, and concentration-dependent cytotoxicity after entry into the body. The parent nucleus of phencyclidine-type substances is arylcyclohexylamine, which is easy to modify; therefore, abusers and dealers can readily synthesize substitutes beyond the drug control catalog. An urgent need exists to establish screening methods for phencyclidine-type substances to provide technical support for abuse monitoring. In this study, 20 mg of hair was pulverized in 500 mL of methanol containing 0.5 ng/mL PCP-d

Identifiants

DOI: 10.1016/j.jpba.2023.115577 PMID: 37480824
pubmed: 37480824
pii: S0731-7085(23)00346-1
doi: 10.1016/j.jpba.2023.115577
pii:
doi:

Substances chimiques

Phencyclidine J1DOI7UV76
Acetonitriles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115577

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Ziyi Li (Z)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

Zehong Li (Z)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

Wanting Xie (W)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

Jinting Liu (J)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China.

Bo Li (B)

School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

Wei Liu (W)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China. Electronic address: liuw@ssfjd.cn.

Yan Shi (Y)

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China. Electronic address: shiy@ssfjd.cn.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Phencyclidine › Hair-based rapid UPLC-MS/MS analysis of 36...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Hair-based rapid UPLC-MS/MS analysis of 36...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Hair-based rapid UPLC-MS/MS analysis of 36...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Hair-based rapid UPLC-MS/MS analysis of 36...
questionsmedicales.fr › Système tégumentaire › Poils › Hair-based rapid UPLC-MS/MS analysis of 36...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Acétonitriles › Hair-based rapid UPLC-MS/MS analysis of 36...