Phytotherapy of abnormality of fear memory: A narrative review of mechanisms.
Drug development
Fear memory
Phytotherapy
Post-traumatic stress disorder
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
23
05
2023
revised:
17
07
2023
accepted:
18
07
2023
medline:
21
8
2023
pubmed:
24
7
2023
entrez:
23
7
2023
Statut:
ppublish
Résumé
It is generally believed that in post-traumatic stress disorder (PTSD), the high expression of fear memory is mainly determined by amygdala hyperactivity and hippocampus hypoactivity. In this review, we firstly updated the mechanisms of fear memory, and then searched the experimental evidence of phytotherapy for fear memory in the past five years. Based on the summary of those experimental studies, we further discussed the future research strategies of plant medicines, including the study of the mechanism of specific brain regions, the optimal time for the prevention and treatment of fear memory-related diseases such as PTSD, and the development of new drugs with active components of plant medicines. Accordingly, plant medicines play a clear role in improving fear memory abnormalities and have the drug development potential in the treatment of fear-related disorders.
Identifiants
pubmed: 37482307
pii: S0367-326X(23)00193-4
doi: 10.1016/j.fitote.2023.105618
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105618Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.