Vasodilators mobilize SK3 channels in endothelial cells to produce arterial relaxation.
Rab11A
SK3 channels
endothelial cells
trafficking
vasodilation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
pmc-release:
26
01
2024
medline:
28
7
2023
pubmed:
26
7
2023
entrez:
26
7
2023
Statut:
ppublish
Résumé
Endothelial cells (ECs) line the lumen of all blood vessels and regulate functions, including contractility. Physiological stimuli, such as acetylcholine (ACh) and intravascular flow, activate transient receptor potential vanilloid 4 (TRPV4) channels, which stimulate small (SK3)- and intermediate (IK)-conductance Ca
Identifiants
pubmed: 37494394
doi: 10.1073/pnas.2303238120
pmc: PMC10401010
doi:
Substances chimiques
Vasodilator Agents
0
TRPV Cation Channels
0
Small-Conductance Calcium-Activated Potassium Channels
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2303238120Subventions
Organisme : American Heart Association-American Stroke Association
ID : AHA855946
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL155186
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL155180
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL166411
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155180
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 20POST35210200
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL166411
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149662
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL158846
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL149662
Pays : United States
Références
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2361-6
pubmed: 24464482
Hypertension. 2018 Sep;72(3):765-775
pubmed: 30012867
Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1151-63
pubmed: 26945080
Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25
pubmed: 19603039
Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17
pubmed: 11252952
J Microsc. 2006 Dec;224(Pt 3):213-32
pubmed: 17210054
J Physiol. 2013 Oct 15;591(20):5031-46
pubmed: 23858011
Br J Pharmacol. 2011 Oct;164(3):839-52
pubmed: 21133895
Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C392-402
pubmed: 26179602
Physiology (Bethesda). 2006 Feb;21:69-78
pubmed: 16443824
J Biol Chem. 2005 Apr 22;280(16):15485-8
pubmed: 15746102
Sci Signal. 2015 Aug 18;8(390):ra83
pubmed: 26286025
J Anat. 2006 Nov;209(5):689-98
pubmed: 17062025
Circ Res. 2009 Apr 24;104(8):987-94
pubmed: 19299646
Nat Rev Mol Cell Biol. 2009 Sep;10(9):597-608
pubmed: 19696797
Cells. 2021 May 11;10(5):
pubmed: 34064835
Sci Signal. 2017 May 09;10(478):
pubmed: 28487419
Elife. 2020 May 04;9:
pubmed: 32364494
J Physiol. 2020 Sep;598(17):3577-3596
pubmed: 32463112
Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1495-502
pubmed: 16675722
Microcirculation. 2018 Jan;25(1):
pubmed: 28963858
Science. 2012 May 4;336(6081):597-601
pubmed: 22556255
J Gen Physiol. 2019 Sep 2;151(9):1116-1134
pubmed: 31371391
Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C318-27
pubmed: 22621787
Oncotarget. 2017 Nov 3;8(63):106149-106150
pubmed: 29290926
Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C885-93
pubmed: 27076616
Elife. 2022 Mar 01;11:
pubmed: 35229718
Physiol Rev. 2011 Jan;91(1):119-49
pubmed: 21248164
Biocell. 1996 Dec;20(3):331-8
pubmed: 9031602
Philos Trans R Soc Lond B Biol Sci. 1994 Jan 29;343(1304):225-46
pubmed: 8146236
Circ Res. 2009 Nov 6;105(10):948-55
pubmed: 19797702
Physiol Rev. 2015 Apr;95(2):645-90
pubmed: 25834234
Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H466-76
pubmed: 19966050
Am J Physiol Cell Physiol. 2010 Sep;299(3):C682-94
pubmed: 20610768
Nat Rev Mol Cell Biol. 2004 Feb;5(2):121-32
pubmed: 15040445
Sci Signal. 2015 Jan 06;8(358):ra2
pubmed: 25564678
Microcirculation. 2013 Apr;20(3):239-47
pubmed: 23311975
Traffic. 2005 Apr;6(4):278-85
pubmed: 15752134
J Biol Chem. 2010 Jun 4;285(23):17938-53
pubmed: 20360009
Circ Res. 2017 Sep 1;121(6):650-661
pubmed: 28696251
Int J Biochem Cell Biol. 2000 Mar;32(3):303-7
pubmed: 10716627
PLoS One. 2007 Sep 05;2(9):e827
pubmed: 17786199
Front Physiol. 2022 Feb 08;13:805149
pubmed: 35211031