Ketolysis drives CD8
CD8(+) T cells
TCA cycle
acetyl-CoA
cancer immunology
effector function
epigenetics
ketolysis
ketone bodies
metabolism
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
12 09 2023
12 09 2023
Historique:
received:
16
09
2022
revised:
07
04
2023
accepted:
04
07
2023
pmc-release:
12
09
2024
medline:
15
9
2023
pubmed:
30
7
2023
entrez:
29
7
2023
Statut:
ppublish
Résumé
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8
Identifiants
pubmed: 37516105
pii: S1074-7613(23)00314-X
doi: 10.1016/j.immuni.2023.07.002
pmc: PMC10528215
mid: NIHMS1921114
pii:
doi:
Substances chimiques
3-Hydroxybutyric Acid
TZP1275679
Histones
0
Ketone Bodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2021-2035.e8Subventions
Organisme : NIAID NIH HHS
ID : R01 AI165722
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI153997
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA251066
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG069781
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128349
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091538
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151345
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124736
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests R.G.J. is a scientific advisor for Agios Pharmaceuticals and Servier Pharmaceuticals and is a member of the Scientific Advisory Board of Immunomet Therapeutics.
Références
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30668551
Cell Metab. 2016 Aug 9;24(2):256-68
pubmed: 27475046
Nature. 2022 Sep;609(7928):801-807
pubmed: 35901960
Immunity. 2019 Dec 17;51(6):1074-1087.e9
pubmed: 31784108
Cold Spring Harb Symp Quant Biol. 2011;76:325-34
pubmed: 22262476
J Immunol. 2006 Jul 15;177(2):1062-9
pubmed: 16818762
Nucleic Acids Res. 2012 Jan;40(Database issue):D809-14
pubmed: 22139941
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):260-266
pubmed: 29697540
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
J Immunol. 2012 Feb 1;188(3):1255-65
pubmed: 22205031
Nat Rev Cancer. 2016 Nov;16(11):732-749
pubmed: 27658529
Nat Immunol. 2013 Apr;14(4):404-12
pubmed: 23396170
Science. 2013 Jan 11;339(6116):211-4
pubmed: 23223453
Genome Biol. 2014;15(12):550
pubmed: 25516281
Trends Immunol. 2021 May;42(5):389-400
pubmed: 33865714
Nature. 2021 Nov;599(7884):302-307
pubmed: 34671163
Cancer Res. 2022 Apr 15;82(8):1575-1588
pubmed: 35247887
Mol Cell. 2016 Apr 21;62(2):194-206
pubmed: 27105115
Annu Rev Nutr. 2021 Oct 11;41:49-77
pubmed: 34633859
Sci Immunol. 2019 Nov 15;4(41):
pubmed: 31732517
Cell Metab. 2019 Feb 5;29(2):383-398.e7
pubmed: 30449686
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nat Med. 2015 Mar;21(3):263-9
pubmed: 25686106
Nat Commun. 2019 Oct 17;10(1):4706
pubmed: 31624246
Cell Rep. 2017 Feb 28;18(9):2077-2087
pubmed: 28249154
Cell Metab. 2017 Feb 7;25(2):345-357
pubmed: 28111214
Nat Rev Immunol. 2012 Nov;12(11):749-61
pubmed: 23080391
Cell. 2017 Apr 06;169(2):258-272.e17
pubmed: 28388410
Nature. 2022 Mar;603(7901):477-481
pubmed: 35264789
Cell. 2016 Sep 8;166(6):1512-1525.e12
pubmed: 27610573
BMC Bioinformatics. 2009 May 27;10:161
pubmed: 19473525
Essays Biochem. 2019 Apr 23;63(1):97-107
pubmed: 30940741
Immunity. 2017 Dec 19;47(6):1129-1141.e5
pubmed: 29246443
J Am Heart Assoc. 2017 Feb 27;6(3):
pubmed: 28242634
J Biol Chem. 2020 Nov 20;295(47):15826-15837
pubmed: 32994221
EMBO J. 2022 May 2;41(9):e110466
pubmed: 35307861
Trends Immunol. 2020 Feb;41(2):113-125
pubmed: 31959515
Nat Metab. 2020 Oct;2(10):1001-1012
pubmed: 32958939
J Physiol. 2023 Apr;601(7):1207-1224
pubmed: 36799478
Immunity. 2019 Nov 19;51(5):856-870.e5
pubmed: 31747582
Cell Metab. 2020 Feb 4;31(2):250-266.e9
pubmed: 32023446
Nature. 2017 May 25;545(7655):452-456
pubmed: 28514453
Immunol Rev. 2014 Sep;261(1):157-68
pubmed: 25123283
Cell. 2017 May 4;169(4):570-586
pubmed: 28475890
Science. 2013 Oct 11;342(6155):1242454
pubmed: 24115444
Front Med (Lausanne). 2022 Jun 16;9:923502
pubmed: 35783654
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Metab. 2020 Jan;2(1):50-61
pubmed: 32694683
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Nat Protoc. 2021 Sep;16(9):4494-4521
pubmed: 34349284
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
JCI Insight. 2021 Jan 25;6(2):
pubmed: 33320838
Nat Cell Biol. 2020 Jan;22(1):18-25
pubmed: 31871320
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Nat Metab. 2020 Aug;2(8):703-716
pubmed: 32747793
Nat Immunol. 2022 Nov;23(11):1614-1627
pubmed: 36289450
Nat Rev Immunol. 2020 Feb;20(2):79-80
pubmed: 31892735
Nat Rev Immunol. 2018 May;18(5):340-356
pubmed: 29379213
Curr Opin Immunol. 2017 Jun;46:viii-xi
pubmed: 28684058
Cell Metab. 2017 Feb 7;25(2):262-284
pubmed: 28178565
PLoS Pathog. 2021 Jul 8;17(7):e1009697
pubmed: 34237114
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Immunity. 2015 Jan 20;42(1):41-54
pubmed: 25607458
J Immunol. 2005 Jun 1;174(11):6791-802
pubmed: 15905520
J Biol Chem. 2017 Apr 28;292(17):7189-7207
pubmed: 28270511
Cancer Res. 2011 Apr 15;71(8):2892-900
pubmed: 21292811
Annu Rev Immunol. 2007;25:171-92
pubmed: 17129182
Nat Immunol. 2019 Jun;20(6):701-710
pubmed: 31110314
Immunity. 2014 Aug 21;41(2):325-38
pubmed: 25148027
Immunity. 2022 Jan 11;55(1):14-30
pubmed: 35021054
Cell Metab. 2022 Sep 6;34(9):1298-1311.e6
pubmed: 35981545
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Nat Rev Immunol. 2022 Apr;22(4):209-223
pubmed: 34253904
Bioinformatics. 2005 Aug 15;21(16):3439-40
pubmed: 16082012
Eur J Immunol. 2008 Sep;38(9):2438-50
pubmed: 18792400
Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E363-74
pubmed: 23233542
EMBO Mol Med. 2021 Aug 9;13(8):e14323
pubmed: 34151532