New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus.
Diterpenoid
Labdane
Leonurus japonicus
Neuroprotective activity
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
17
02
2023
medline:
1
8
2023
pubmed:
31
7
2023
entrez:
30
7
2023
Statut:
ppublish
Résumé
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
Identifiants
pubmed: 37517822
pii: S1875-5364(23)60446-7
doi: 10.1016/S1875-5364(23)60446-7
pii:
doi:
Substances chimiques
Diterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
551-560Informations de copyright
Copyright © 2023 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.