The role of functional and structural properties of the nucleus accumbens subregions in eating behavior regulation of bulimia nervosa.
bulimia nervosa
eating behavior
fractional amplitude of low-frequency fluctuation
functional connectivity
gray matter volume
nucleus accumbens
Journal
The International journal of eating disorders
ISSN: 1098-108X
Titre abrégé: Int J Eat Disord
Pays: United States
ID NLM: 8111226
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
24
07
2023
received:
08
03
2023
accepted:
24
07
2023
medline:
17
11
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Although studies have demonstrated the involvement of the nucleus accumbens (NAc) in the neurobiology of eating disorders, its alterations in bulimia nervosa (BN) remain largely unknown. This study investigated the structural and functional properties of NAc in patients with BN. Based on the resting-state functional MRI and high-resolution anatomical T1-weighted imaging data acquired from 43 right-handed BN patients and 40 sex-, age- and education-matched right-handed healthy controls (HCs), the group differences in gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) in slow-4 and -5 bands and functional connectivity (FC) of NAc subregions (core and shell) were compared. The relationships between MRI and clinical data were explored in the BN group. Compared with HCs, BN patients showed preserved GMV, decreased fALFF in slow-5 band of the left NAc core and shell, decreased FC between left NAc core and right caudate, and increased FC between all NAc subregions and frontal regions, between all NAc subregions (except the right NAc core) and the supramarginal gyrus (SMG), and between right NAc shell and left middle temporal gyrus. FC between the NAc and SMG was correlated with emotional eating behaviors. Our study revealed preserved GMV, local neuronal activity reduction and functional network reorganization of the NAc in BN. The functional network reorganization of the NAc mainly occurred in the frontal cortex and was correlated with emotional eating behavior. These findings may provide novel insights into the BN using NAc as an entry point. Although studies have demonstrated the involvement of the nucleus accumbens (NAc) in the neurobiology of eating disorders, its alterations in bulimia nervosa (BN) remain largely unknown. We used a multimodal MRI technique to systematically investigate structural and functional alterations in NAc subregions of BN patients and explored the associations between such alterations and maladaptive eating behaviors, hoping to provide novel insights into BN.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2084-2095Subventions
Organisme : Beijing Friendship Hospital, Capital Medical University
ID : YYZZ201917
Organisme : Beijing Hospitals Authority Youth Programme
ID : QML20191902
Organisme : Beijing Key Clinical Discipline Funding
ID : 2021-135
Organisme : Beijing Key Laboratory of Mental Disorders
ID : 2021JSJB03
Organisme : Beijing Scholar 2015
Organisme : National Natural Science Foundation of China
ID : 82001790
Organisme : the postdoctoral launch project of Beijing Friendship Hospital, Capital Medical University
ID : No.yybsh2022003
Informations de copyright
© 2023 Wiley Periodicals LLC.
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