A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
02 08 2023
02 08 2023
Historique:
medline:
4
8
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Host-derived succinate accumulates in the airways during bacterial infection. Here, we show that luminal succinate activates murine tracheal brush (tuft) cells through a signaling cascade involving the succinate receptor 1 (SUCNR1), phospholipase Cβ2, and the cation channel transient receptor potential channel subfamily M member 5 (TRPM5). Stimulated brush cells then trigger a long-range Ca
Identifiants
pubmed: 37531421
doi: 10.1126/sciadv.adg8842
pmc: PMC10396310
doi:
Substances chimiques
Acetylcholine
N9YNS0M02X
Succinates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg8842Références
Cell Calcium. 2010 Aug-Sep;48(2-3):102-13
pubmed: 20883893
Nat Neurosci. 2009 Dec;12(12):1551-8
pubmed: 19935653
Int J Mol Sci. 2021 Sep 11;22(18):
pubmed: 34575997
Infect Immun. 2006 Sep;74(9):4970-81
pubmed: 16926388
J Helminthol. 1967;41(4):285-90
pubmed: 6057041
Sci Immunol. 2020 Jan 17;5(43):
pubmed: 31953256
Sci Transl Med. 2019 Jul 3;11(499):
pubmed: 31270271
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7260-5
pubmed: 10860991
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7971-5
pubmed: 9223297
Sci Immunol. 2022 Mar 4;7(69):eabf6734
pubmed: 35245090
J Vis Exp. 2019 Jun 12;(148):
pubmed: 31259891
Immunity. 2020 Apr 14;52(4):683-699.e11
pubmed: 32294408
Science. 2020 Nov 20;370(6519):
pubmed: 33214249
PLoS One. 2017 Dec 7;12(12):e0189340
pubmed: 29216297
Neuron. 2015 Mar 04;85(5):942-58
pubmed: 25741722
Exp Cell Res. 2015 Jun 10;334(2):260-9
pubmed: 25770012
Ann Transl Med. 2019 Dec;7(Suppl 8):S263
pubmed: 32015982
Chem Senses. 2015 Jul;40(6):413-25
pubmed: 25940069
J Pharm Pharmacol. 1985 Sep;37(9):656-8
pubmed: 2867189
Int Forum Allergy Rhinol. 2023 Aug;13(8):1525-1534
pubmed: 36565436
Nat Neurosci. 2010 Jan;13(1):133-40
pubmed: 20023653
Nat Neurosci. 2002 Nov;5(11):1169-76
pubmed: 12368808
Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C141-C154
pubmed: 29631365
Gastroenterology. 2020 Dec;159(6):2101-2115.e5
pubmed: 32828819
J Clin Invest. 2014 Mar;124(3):1393-405
pubmed: 24531552
Chem Senses. 2006 Mar;31(3):253-64
pubmed: 16436689
Sci Rep. 2018 Apr 9;8(1):5681
pubmed: 29632402
Front Cell Neurosci. 2014 Oct 21;8:306
pubmed: 25374505
J Cell Biol. 2000 Sep 18;150(6):1349-60
pubmed: 10995440
BMC Neurosci. 2008 Nov 24;9:114
pubmed: 19025635
J Biol Chem. 2009 May 29;284(22):14875-80
pubmed: 19363029
Am J Respir Crit Care Med. 2021 May 15;203(10):1275-1289
pubmed: 33321047
J Neurosci. 2014 Apr 9;34(15):5121-33
pubmed: 24719092
Immunity. 2018 Jul 17;49(1):33-41.e7
pubmed: 30021144
Int Immunopharmacol. 2020 Jul;84:106496
pubmed: 32304995
Science. 2004 Nov 5;306(5698):1033-7
pubmed: 15528444
J Clin Invest. 2022 Jul 1;132(13):
pubmed: 35503420
Sci Rep. 2017 Aug 31;7(1):10260
pubmed: 28860523
BMC Biol. 2006 Mar 30;4:7
pubmed: 16573824
Mol Pain. 2011 Sep 11;7:66
pubmed: 21906401
Life Sci. 2012 Nov 27;91(21-22):1009-12
pubmed: 22771693
Dev Cell. 2022 Sep 26;57(18):2221-2236.e5
pubmed: 36108628
J Biomed Biotechnol. 2011;2011:174306
pubmed: 22131798
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557
pubmed: 29735652
Nat Neurosci. 2011 Jun;14(6):685-7
pubmed: 21572433
Cell Tissue Res. 1980;208(1):65-84
pubmed: 6248229
Eur J Pharmacol. 2016 Jun 15;781:100-8
pubmed: 27063443
Mol Cell Neurosci. 2017 Apr;80:75-88
pubmed: 28188885
Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1868-902
pubmed: 8970383
Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L614-24
pubmed: 16963528
JCI Insight. 2022 Jul 8;7(13):
pubmed: 35608904
J Parasitol. 1992 Feb;78(1):24-9
pubmed: 1738065
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3210-5
pubmed: 20133764
Am J Physiol Cell Physiol. 2001 Jun;280(6):C1485-97
pubmed: 11350744
Nature. 2018 Aug;560(7718):377-381
pubmed: 30069046
Front Cell Neurosci. 2018 Mar 20;12:71
pubmed: 29615870
Sci Rep. 2019 Jun 20;9(1):8834
pubmed: 31222082
Cell Calcium. 2015 Dec;58(6):638-48
pubmed: 26572560
Cell Syst. 2019 Apr 24;8(4):281-291.e9
pubmed: 30954476
Sci Immunol. 2018 Oct 5;3(28):
pubmed: 30291131
Eur J Neurosci. 2014 Jun;39(11):1720-8
pubmed: 24405482
BMC Pulm Med. 2011 Jan 13;11:3
pubmed: 21232137
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12898-903
pubmed: 21768373
Eur Respir J. 2009 May;33(5):1113-21
pubmed: 19213795
Lancet. 2021 Jun 5;397(10290):2195-2211
pubmed: 34090606
Cell. 2018 Jul 12;174(2):271-284.e14
pubmed: 29887373
Sci Immunol. 2021 Mar 5;6(57):
pubmed: 33674321
Br J Pharmacol. 2012 Jun;166(4):1388-402
pubmed: 22300281
Pflugers Arch. 2018 Sep;470(9):1335-1348
pubmed: 29860639
Respir Res. 2020 Dec 10;21(1):326
pubmed: 33302964
Cells. 2022 Aug 04;11(15):
pubmed: 35954259
Brain Res Mol Brain Res. 1999 Feb 5;64(2):246-54
pubmed: 9931497
Annu Rev Physiol. 1990;52:115-35
pubmed: 2158763
BMC Neurosci. 2001;2:6
pubmed: 11346454
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143
pubmed: 30804203
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6075-80
pubmed: 24711432
FASEB J. 2020 Jan;34(1):316-332
pubmed: 31914675
Am J Physiol Lung Cell Mol Physiol. 2000 Oct;279(4):L623-30
pubmed: 11000121
Physiol Rep. 2017 Jun;5(12):
pubmed: 28642338
J Physiol. 2017 Jul 15;595(14):4755-4767
pubmed: 28422293
Nature. 2018 Aug;560(7718):319-324
pubmed: 30069044
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9478-83
pubmed: 21606356
Nat Commun. 2018 Jan 12;9(1):177
pubmed: 29330456
J Immunol. 2008 Apr 1;180(7):4986-93
pubmed: 18354224
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923