Advancing evolution: Bacteria break down gene silencer to express horizontally acquired genes.
Lon
PhoP
heat-stable nucleoid-structuring protein
horizontal gene transfer
transcription
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
revised:
25
07
2023
received:
09
04
2023
accepted:
28
07
2023
pmc-release:
01
10
2024
medline:
22
9
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Horizontal gene transfer advances bacterial evolution. To benefit from horizontally acquired genes, enteric bacteria must overcome silencing caused when the widespread heat-stable nucleoid structuring (H-NS) protein binds to AT-rich horizontally acquired genes. This ability had previously been ascribed to both anti-silencing proteins outcompeting H-NS for binding to AT-rich DNA and RNA polymerase initiating transcription from alternative promoters. However, we now know that pathogenic Salmonella enterica serovar Typhimurium and commensal Escherichia coli break down H-NS when this silencer is not bound to DNA. Curiously, both species use the same protease - Lon - to destroy H-NS in distinct environments. Anti-silencing proteins promote the expression of horizontally acquired genes without binding to them by displacing H-NS from AT-rich DNA, thus leaving H-NS susceptible to proteolysis and decreasing H-NS amounts overall. Conserved amino acid sequences in the Lon protease and H-NS cleavage site suggest that diverse bacteria degrade H-NS to exploit horizontally acquired genes.
Identifiants
pubmed: 37533411
doi: 10.1002/bies.202300062
pmc: PMC10530229
mid: NIHMS1923003
doi:
Substances chimiques
DNA-Binding Proteins
0
Bacterial Proteins
0
DNA-Directed RNA Polymerases
EC 2.7.7.6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300062Subventions
Organisme : NIAID NIH HHS
ID : R01 AI049561
Pays : United States
Informations de copyright
© 2023 Wiley Periodicals LLC.
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