Unique functional responses differentially map onto genetic subtypes of dopamine neurons.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
23
09
2022
accepted:
05
07
2023
medline:
4
10
2023
pubmed:
4
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine neuron subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1 and Anxa1, each have a unique set of responses to rewards, aversive stimuli and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes. Remarkably, reward responses were almost entirely absent in the Anxa1
Identifiants
pubmed: 37537242
doi: 10.1038/s41593-023-01401-9
pii: 10.1038/s41593-023-01401-9
pmc: PMC10545540
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1762-1774Subventions
Organisme : NIDA NIH HHS
ID : P50 DA044121
Pays : United States
Organisme : NIH HHS
ID : S10 OD011996
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110556
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS119690
Pays : United States
Organisme : NIH HHS
ID : S10 OD026814
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS115524
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008152
Pays : United States
Organisme : NIH HHS
ID : S10 OD025120
Pays : United States
Informations de copyright
© 2023. The Author(s).
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