IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption.
IFI27
brown adipocyte
metabolic adaption
mitochondria
thermogenesis
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
revised:
16
06
2023
received:
22
03
2023
medline:
9
10
2023
pubmed:
7
8
2023
entrez:
6
8
2023
Statut:
ppublish
Résumé
Mitochondria are the pivot organelles to control metabolism and energy homeostasis. The capacity of mitochondrial metabolic adaptions to cold stress is essential for adipocyte thermogenesis. How brown adipocytes keep mitochondrial fitness upon a challenge of cold-induced oxidative stress has not been well characterized. This manuscript shows that IFI27 plays an important role in cristae morphogenesis, keeping intact succinate dehydrogenase (SDH) function and active fatty acid oxidation to sustain thermogenesis in brown adipocytes. IFI27 protein interaction map identifies SDHB and HADHA as its binding partners. IFI27 physically links SDHB to chaperone TNF receptor associated protein 1 (TRAP1), which shields SDHB from oxidative damage-triggered degradation. Moreover, IFI27 increases hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA) catalytic activity in β-oxidation pathway. The reduced SDH level and fatty acid oxidation in Ifi27-knockout brown fat results in impaired oxygen consumption and defective thermogenesis. Thus, IFI27 is a novel regulator of mitochondrial metabolism and thermogenesis.
Identifiants
pubmed: 37544897
doi: 10.1002/advs.202301855
pmc: PMC10558685
doi:
Substances chimiques
Succinic Acid
AB6MNQ6J6L
Fatty Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301855Subventions
Organisme : National Key Technologies R&D Program of China
ID : 2018YFA0800401
Organisme : National Natural Science Foundation of China
ID : 32171140
Organisme : National Natural Science Foundation of China
ID : 31970710
Organisme : Program of Shanghai Academic Research Leader
ID : 22XD1400500
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
Essays Biochem. 2016 Oct 15;60(2):213-225
pubmed: 27744337
Sci Adv. 2023 Feb 3;9(5):eade8701
pubmed: 36735777
Int J Mol Med. 2020 Aug;46(2):663-674
pubmed: 32626957
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
Adv Sci (Weinh). 2023 Oct;10(28):e2301855
pubmed: 37544897
Integr Comp Biol. 2018 Sep 1;58(3):519-531
pubmed: 29701785
Cell Metab. 2014 Mar 4;19(3):445-57
pubmed: 24606901
Cell Rep. 2015 Dec 1;13(9):2000-13
pubmed: 26628366
Mol Cell Biol. 2006 Feb;26(3):762-76
pubmed: 16428434
Lancet Oncol. 2009 Aug;10(8):764-71
pubmed: 19576851
Cell Rep. 2014 Aug 7;8(3):671-7
pubmed: 25088416
Diabetes. 2022 Jul 1;71(7):1439-1453
pubmed: 35472723
Nat Metab. 2019 Feb;1(2):189-200
pubmed: 31903450
FASEB J. 2020 Jan;34(1):303-315
pubmed: 31914648
Trends Biochem Sci. 2017 Apr;42(4):312-325
pubmed: 28185716
Nat Commun. 2019 Oct 11;10(1):4671
pubmed: 31604922
Nature. 2018 Aug;560(7716):102-106
pubmed: 30022159
Cell Metab. 2021 Mar 2;33(3):598-614.e7
pubmed: 33592173
Nature. 2016 Apr 7;532(7597):112-6
pubmed: 27027295
Cell Death Dis. 2013 Jan 17;4:e467
pubmed: 23328674
Nat Cell Biol. 2015 Oct;17(10):1317-26
pubmed: 26302408
Cell Metab. 2009 Oct;10(4):324-35
pubmed: 19808025
Eur J Cell Biol. 2020 Jan;99(1):151057
pubmed: 31810635
J Clin Invest. 2019 Feb 1;129(2):694-711
pubmed: 30511960
Sci Adv. 2023 Feb 24;9(8):eade7864
pubmed: 36827367
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986
pubmed: 28630339
Cell Metab. 2014 Aug 5;20(2):253-66
pubmed: 24954417
Mol Cell. 2019 May 16;74(4):844-857.e7
pubmed: 31000437
Cell Metab. 2021 Dec 7;33(12):2464-2483.e18
pubmed: 34800366
Biochim Biophys Acta. 2013 Feb;1833(2):388-99
pubmed: 22705353
Dev Cell. 2015 Dec 7;35(5):568-583
pubmed: 26625958
Nat Commun. 2013;4:2139
pubmed: 23842546
Nat Protoc. 2017 Sep;12(9):1792-1816
pubmed: 28796234
EMBO J. 2017 Jun 1;36(11):1528-1542
pubmed: 28408438
Cell Calcium. 2021 Mar;94:102343
pubmed: 33418313
BMC Genomics. 2004 Jan 19;5(1):8
pubmed: 14728724
Cell Metab. 2016 Feb 9;23(2):292-302
pubmed: 26749241
Biochem Biophys Res Commun. 2018 Jun 18;501(1):273-279
pubmed: 29730295
Nat Rev Mol Cell Biol. 2021 Jan;22(1):54-70
pubmed: 33093673
Nat Cell Biol. 2020 Apr;22(4):476-486
pubmed: 32231310
Nat Methods. 2015 Jan;12(1):51-4
pubmed: 25419960
Nature. 1997 May 1;387(6628):90-4
pubmed: 9139827
Proteomics. 2010 Apr;10(7):1426-43
pubmed: 20186747
Nat Rev Mol Cell Biol. 2022 Dec;23(12):817-835
pubmed: 35804199
Cell Mol Life Sci. 2019 Oct;76(20):4023-4042
pubmed: 31236625
Cell Rep. 2022 Dec 13;41(11):111806
pubmed: 36516764
Biochim Biophys Acta. 2014 Apr 4;1841(4):595-609
pubmed: 24316057
Int J Mol Sci. 2017 May 24;18(6):
pubmed: 28538669
J Biol Chem. 2016 Nov 25;291(48):24880-24891
pubmed: 27694445
Nat Genet. 1995 Oct;11(2):144-9
pubmed: 7550341
Experientia Suppl. 1978;32:147-51
pubmed: 274305
Cell Physiol Biochem. 2015;36(5):2072-82
pubmed: 26202366
J Hepatol. 2021 Aug;75(2):387-399
pubmed: 33746082
Oxid Med Cell Longev. 2017;2017:3647657
pubmed: 29445445
Open Biol. 2021 Dec;11(12):210238
pubmed: 34847778
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8
pubmed: 11867749
Science. 2022 Oct 28;378(6618):eabj3510
pubmed: 36302005
Nat Protoc. 2006;1(1):418-28
pubmed: 17406264