Blocked Autophagy is Involved in Layered Double Hydroxide-Induced Repolarization and Immune Activation in Tumor-Associated Macrophages.
autophagy
layered double hydroxide
repolarization
tumor-associated macrophages
tumor immunotherapy
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
01
08
2023
received:
08
05
2023
medline:
5
12
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment (TME). The polar plasticity of TAMs makes them important targets for improving the immunosuppressive microenvironment of tumors. The previous study reveals that layered double hydroxides (LDHs) can effectively promote the polarization of TAMs from the anti-inflammatory M2 type to the pro-inflammatory M1 type. However, their mechanisms of action remain unexplored. This study reveals that LDHs composed of different cations exhibit distinct abilities to regulate the polarity of TAMs. Compared to Mg-Fe LDH, Mg-Al LDH has a stronger ability to promote the repolarization of TAMs from M2 to M1 and inhibit the formation of myeloid-derived suppressor cells (MDSCs). In addition, Mg-Al LDH restrains the growth of tumors in vivo and promotes the infiltration of activated immune cells into the TME more effectively. Interestingly, Mg-Al LDH influences the autophagy of TAMs; this negatively correlates with the pro-inflammatory ability of TAMs. Therefore, LDHs exert their polarization ability by inhibiting the autophagy of TAMs, and this mechanism might be related to the ionic composition of LDHs. This study lays the foundation for optimizing the performance of LDH-based immune adjuvants, which display excellent application prospects for tumor immunotherapy.
Identifiants
pubmed: 37549006
doi: 10.1002/adhm.202301471
doi:
Substances chimiques
hydroxide ion
9159UV381P
Adjuvants, Immunologic
0
Hydroxides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301471Subventions
Organisme : National Natural Science Foundation of China
ID : 32071401
Organisme : Shanghai Natural Science Foundation
ID : 20ZR1461600
Organisme : China Postdoctoral Science Foundation
ID : 2021M691442
Organisme : Anhui Natural Science Foundation
ID : 2108085QC107
Organisme : Foundation of Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College
ID : KFZZ202202
Informations de copyright
© 2023 Wiley-VCH GmbH.
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