Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system.
Ubiquitin
bacterial effector
bacterial pathogenesis
post-translational modification
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
18 09 2023
18 09 2023
Historique:
revised:
10
07
2023
received:
19
04
2023
accepted:
18
07
2023
pmc-release:
09
08
2024
medline:
19
9
2023
pubmed:
9
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
Regulation through post-translational ubiquitin signaling underlies a large portion of eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have evolved mechanisms to manipulate or subvert the host ubiquitin system. Bacteria are particularly adept at this and rely heavily upon ubiquitin-targeted virulence factors for invasion and replication. Despite lacking a conventional ubiquitin system of their own, many bacterial ubiquitin regulators loosely follow the structural and mechanistic rules established by eukaryotic ubiquitin machinery. Others completely break these rules and have evolved novel structural folds, exhibit distinct mechanisms of regulation, or catalyze foreign ubiquitin modifications. Studying these interactions can not only reveal important aspects of bacterial pathogenesis but also shed light on unexplored areas of ubiquitin signaling and regulation. In this review, we discuss the methods by which bacteria manipulate host ubiquitin and highlight aspects that follow or break the rules of ubiquitination.
Identifiants
pubmed: 37555693
doi: 10.15252/embj.2023114318
pmc: PMC10505922
doi:
Substances chimiques
Ubiquitin
0
Bacterial Proteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e114318Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM142486
Pays : United States
Informations de copyright
© 2023 The Authors.
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