Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Humans Autoimmune Diseases / immunology Autoimmunity Central Nervous System / cytology Dendritic Cells / immunology Hypoxia-Inducible Factor 1, alpha Subunit / chemistry Lactic Acid / metabolism Probiotics / therapeutic use Reactive Oxygen Species / metabolism T-Lymphocytes / immunology Feedback, Physiological Lactase / genetics Single-Cell Analysis

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
Aug 2023

Historique:

received: 09 11 2021

accepted: 06 07 2023

medline: 25 8 2023

pubmed: 10 8 2023

entrez: 9 8 2023

Statut: ppublish

Résumé

Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells

Identifiants

DOI: 10.1038/s41586-023-06409-6 PMID: 37558878

pubmed: 37558878

doi: 10.1038/s41586-023-06409-6

pii: 10.1038/s41586-023-06409-6

doi:

Substances chimiques

HIF1A protein, human 0

Hypoxia-Inducible Factor 1, alpha Subunit 0

Lactic Acid 33X04XA5AT

NDUFA4L2 protein, human 0

Reactive Oxygen Species 0

XBP1 protein, human 0

Lactase EC 3.2.1.108

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

881-889

Subventions

Organisme : NINDS NIH HHS

ID : R00 NS114111

Pays : United States

Organisme : NIMH NIH HHS

ID : R01 MH130458

Pays : United States

Commentaires et corrections

Type : UpdateOf

Type : CommentIn

Informations de copyright

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